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Literature summary extracted from

  • Jefferson, A.B.; Majerus, P.W.
    Properties of type II inositol polyphosphate 5-phosphatase (1995), J. Biol. Chem., 270, 9370-9377.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.56 expressed in Sf9 insect cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.56 C939S eliminates isoprenylation of enzyme which reduces activity towards phosphatidylinositol 4,5-bisphosphate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 phosphatidylinositol 4-phosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 inositol 4,5-bisphosphate + H2O Homo sapiens
-
 inositol 4-phosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.56 side-chain modification isoprenylation at Cys-939 Homo sapiens
3.1.3.56 side-chain modification isoprenylation Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 inositol 4,5-bisphosphate + H2O
-
 Homo sapiens inositol 4-phosphate + phosphate
-
 ?