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Literature summary extracted from

  • Hansbro, P.M.; Foster, P.S.; Hogan, S.P.; Ozaki, S.; Denborough, M.A.
    Purification and characterization of D-myo-inositol (1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase from skeletal muscle (1994), Arch. Biochem. Biophys., 311, 47-54.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.56 2,3-bisphosphoglycerate
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.56 0.0011
-
 D-myo-Inositol 1,3,4,5-tetrakisphosphate type I enzyme, pH 7.5, 37°C Sus scrofa
3.1.3.56 0.0089
-
 D-myo-inositol 1,4,5-trisphosphate type I enzyme, pH 7.5, 37°C Sus scrofa
3.1.3.56 0.0714
-
 D-myo-inositol 1,4,5-trisphosphate type II enzyme, pH 7.5, 37°C Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.56 membrane
-
 Sus scrofa 16020
-
3.1.3.56 soluble 83% of total activity Sus scrofa
-
-
3.1.3.56 soluble two different soluble enzymes, type I and type II Sus scrofa
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.56 Mg2+
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.56 48000
-
 SDS-PAGE, type I enzyme Sus scrofa
3.1.3.56 81000
-
 gel filtration, type II enzyme Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Sus scrofa
-
 D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Sus scrofa involved in regulation of excitation-contraction coupling in skeletal muscle D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Sus scrofa regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.56 type I enzyme Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 muscle skeletal muscle Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.56 2.54
-
 purified type I enzyme, pH 7.5, 37°C Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O type I and type II enzyme Sus scrofa D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O involved in regulation of excitation-contraction coupling in skeletal muscle Sus scrofa D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Sus scrofa D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?