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Literature summary extracted from

  • Safrany, S.T.; Mills, S.J.; Liu, C.; Lampe, D.; Noble, N.J.; Nahorski, S.R.; Potter, B.V.L.
    Design of potent and selective inhibitors of myo-inositol 1,4,5-trisphosphate 5-phosphatase (1994), Biochemistry, 33, 10763-10769.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.56 medicine potential target for drugs Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.56 L-chiro-Inositol 1,4,6-trisphosphorothioate very potent inhibitor Homo sapiens
3.1.3.56 L-chiro-Inositol 1,4,6-trisphosphorothioate very potent inhibitor Rattus norvegicus
3.1.3.56 L-chiro-Inositol 2,3,5-trisphosphorothioate very potent inhibitor Homo sapiens
3.1.3.56 L-chiro-Inositol 2,3,5-trisphosphorothioate very potent inhibitor Rattus norvegicus
3.1.3.56 L-myo-inositol 1,3,5-trisphosphorothioate very potent inhibitor Homo sapiens
3.1.3.56 L-myo-inositol 1,3,5-trisphosphorothioate very potent inhibitor Rattus norvegicus
3.1.3.56 L-myo-inositol 1,4,5-trisphosphorothioate very potent inhibitor Homo sapiens
3.1.3.56 L-myo-inositol 1,4,5-trisphosphorothioate very potent inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Rattus norvegicus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Homo sapiens
-
 SH-SY5Y neuroblastoma cells
-
3.1.3.56 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 brain
-
 Rattus norvegicus
-
3.1.3.56 erythrocyte ghosts Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.56 0.00000023
-
 L-chiro-Inositol 2,3,5-trisphosphorothioate
-
 Homo sapiens
3.1.3.56 0.0000003
-
 L-chiro-Inositol 1,4,6-trisphosphorothioate
-
 Homo sapiens
3.1.3.56 0.00000043
-
 L-myo-inositol 1,4,5-trisphosphorothioate
-
 Homo sapiens
3.1.3.56 0.00000052
-
 L-myo-inositol 1,3,5-trisphosphorothioate
-
 Homo sapiens