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Literature summary extracted from

  • Höer, A.; Oberdisse, E.
    Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate are inhibitors of the soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase and the inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase from pig brain (1991), Biochem. J., 278, 219-224.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.62 Ammonium phosphate buffer 1 to 10 mM activates, higher concentrations are inhibitory Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.56 ammonium phosphate
-
 Sus scrofa
3.1.3.56 Inositol 1,3,4,5,6-pentakisphosphate
-
 Sus scrofa
3.1.3.56 Inositol hexakisphosphate competitive Sus scrofa
3.1.3.62 Ammonium phosphate buffer 1 to 10 mM activates, higher concentrations are inhibitory Sus scrofa
3.1.3.62 Inositol 1,3,4,5,6-pentakisphosphate strong, kinetics Sus scrofa
3.1.3.62 Inositol hexakisphosphate more effective than inositol pentakisphosphate; strong, kinetics Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.62 soluble
-
 Sus scrofa
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.62 additional information Mg2+-independent Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Sus scrofa product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Sus scrofa
-
 D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.62 additional information Sus scrofa role in the metabolism of inositol phosphates, but probably no important participant in signal transduction ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Sus scrofa
-
-
-
3.1.3.62 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.62 partial Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 brain
-
 Sus scrofa
-
3.1.3.62 brain
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate Sus scrofa D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.62 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?
3.1.3.62 additional information role in the metabolism of inositol phosphates, but probably no important participant in signal transduction Sus scrofa ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.62 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.62 7.4
-
 assay at Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.56 0.01
-
 Inositol hexakisphosphate with inositol 1,4,5-trisphosphate as substrate Sus scrofa
3.1.3.56 0.015
-
 Inositol hexakisphosphate with inositol 1,3,4,5-tetrakisphosphate as substrate Sus scrofa
3.1.3.56 0.02
-
 Inositol 1,3,4,5,6-pentakisphosphate with inositol 1,4,5-trisphosphate as substrate Sus scrofa
3.1.3.56 0.035
-
 Inositol 1,3,4,5,6-pentakisphosphate with inositol 1,3,4,5-tetrakisphosphate as substrate Sus scrofa
3.1.3.62 0.000003
-
 Inositol hexakisphosphate pH 7.4, 37°C Sus scrofa
3.1.3.62 0.00006
-
 Inositol 1,3,4,5,6-pentakisphosphate pH 7.4, 37°C Sus scrofa