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Literature summary extracted from
- Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate inhibit inositol-1,3,4,5-tetrakisphosphate 3-phosphatase in rat parotid glands (1990), J. Biol. Chem., 265, 9869-9875.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.62 | Ammonium phosphate buffer | not below 0.2 mM | Rattus norvegicus |  |
| 3.1.3.62 | Endogenous heat-stable inhibitor | - |
Rattus norvegicus | |
| 3.1.3.62 | Inositol 1,3,4,5,6-pentakisphosphate | 0.001 mM, 50% inhibition; competitive; strong, kinetics | Rattus norvegicus | |
| 3.1.3.62 | inositol 1,3,4-trisphosphate | 0.05 mM, about 50% inhibition | Rattus norvegicus | |
| 3.1.3.62 | Inositol 1,4,5-trisphosphate | 0.05 mM, about 50% inhibition | Rattus norvegicus | |
| 3.1.3.62 | inositol 3,4,5,6-tetrakisphosphate | 0.01 mM, 40% inhibition | Rattus norvegicus | |
| 3.1.3.62 | Inositol hexakisphosphate | mixed inhibitor, 0.001 mM, 85% inhibition; more effective than inositol pentakisphosphate; strong, kinetics | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.3.56 | 0.019 | - |
D-myo-Inositol 1,3,4,5-tetrakisphosphate | pH 7.2, 37°C | Rattus norvegicus | |
| 3.1.3.62 | additional information | - |
additional information | kinetic data of the cytosolic enzyme | Rattus norvegicus | |
| 3.1.3.62 | 0.007 | 0.008 | D-myo-Inositol 1,3,4,5-tetrakisphosphate | pH 7.2, 37°C, cytosolic enzyme | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.56 | soluble | - |
Rattus norvegicus | - |
- |
| 3.1.3.62 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 3.1.3.62 | particle-bound | - |
Rattus norvegicus | - |
- |
| 3.1.3.62 | soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.62 | Mg2+ | Mg2+-dependent | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.56 | D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | Rattus norvegicus | - |
D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
| 3.1.3.56 | D-myo-inositol 1,4,5-trisphosphate + H2O | Rattus norvegicus | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| 3.1.3.62 | additional information | Rattus norvegicus | inositol 1,3,4,5-tetrakisphosphate 3-phosphatase is unlikely to be an important activity in vivo | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.56 | Rattus norvegicus | - |
- |
- |
| 3.1.3.62 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.3.62 | partial | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.56 | parotid gland | - |
Rattus norvegicus | - |
| 3.1.3.62 | parotid gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.56 | D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
| 3.1.3.56 | D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| 3.1.3.56 | D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| 3.1.3.62 | D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 1,4,5-trisphosphate + phosphate | - |
? | |
| 3.1.3.62 | additional information | inositol 1,3,4,5-tetrakisphosphate 3-phosphatase is unlikely to be an important activity in vivo | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.62 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.62 | 7.2 | - |
assay at | Rattus norvegicus |
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