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Literature summary extracted from

  • Milani, D.; Volpe, P.; Pozzan, T.
    D-myo-Inositol 1,4,5-trisphosphate phosphatase in skeletal muscle (1988), Biochem. J., 254, 525-529.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.56 2,3-bisphosphoglycerate
-
 Frog
3.1.3.56 2,3-bisphosphoglycerate
-
 Oryctolagus cuniculus
3.1.3.56 ATP
-
 Frog
3.1.3.56 ATP
-
 Oryctolagus cuniculus
3.1.3.56 CdCl2
-
 Oryctolagus cuniculus
3.1.3.56 D-fructose 1,6-bisphosphate
-
 Oryctolagus cuniculus
3.1.3.56 D-fructose 2,6-bisphosphate
-
 Oryctolagus cuniculus
3.1.3.56 D-Glucose 1,6-bisphosphate
-
 Oryctolagus cuniculus
3.1.3.56 EDTA
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.56 0.016 0.019 D-myo-inositol 1,4,5-trisphosphate membrane bound enzyme, pH 7.2, 30°C Oryctolagus cuniculus
3.1.3.56 0.024
-
 D-myo-inositol 1,4,5-trisphosphate soluble enzyme, pH 7.2, 30°C Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.56 membrane sarcotubular membrane, 60-65% of total activity Oryctolagus cuniculus 16020
-
3.1.3.56 soluble 35-40% of total activity Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Oryctolagus cuniculus involved in regulation of excitation-contraction coupling in skeletal muscle D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Oryctolagus cuniculus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Frog regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Frog
-
-
-
3.1.3.56 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 brain
-
 Oryctolagus cuniculus
-
3.1.3.56 liver
-
 Oryctolagus cuniculus
-
3.1.3.56 muscle fast-twitch skeletal muscle Oryctolagus cuniculus
-
3.1.3.56 muscle fast-twitch skeletal muscle Frog
-
3.1.3.56 muscle smooth muscle of pulmonary artery Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.56 0.0006
-
 muscle, pH 7.2, 30°C Frog
3.1.3.56 0.0014
-
 muscle and liver, pH 7.2, 30°C Oryctolagus cuniculus
3.1.3.56 0.003
-
 main pulmonary artery, pH 7.2, 30°C Oryctolagus cuniculus
3.1.3.56 0.0047
-
 brain, pH 7.2, 30°C Oryctolagus cuniculus
3.1.3.56 0.02
-
 Vmax, membrane fraction, pH 7.2, 30°C Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Oryctolagus cuniculus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Frog D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O involved in regulation of excitation-contraction coupling in skeletal muscle Oryctolagus cuniculus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Oryctolagus cuniculus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Frog D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?