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Literature summary extracted from

  • Erneux, C.; Lemos, M.; Verjans, B.; Vanderhaeghen, P.; Delvaux, A.; Dumont, J.E.
    Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain (1989), Eur. J. Biochem., 181, 317-322.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.56 0.001
-
 D-myo-inositol 1,4,5-trisphosphate pH 7.4, 37°C Bos taurus
3.1.3.56 0.011
-
 D-myo-Inositol 1,3,4,5-tetrakisphosphate pH 7.4, 37°C Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.56 membrane 85-90% of total activity, can be solubilized by cholate or to lesser extent by 2 M KCl Bos taurus 16020
-
3.1.3.56 soluble 10-15% of total activity Bos taurus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.56 37000
-
 gel filtration without cholate, type I enzyme Bos taurus
3.1.3.56 48000
-
 SDS-PAGE, type I enzyme Bos taurus
3.1.3.56 51000
-
 gel filtration in presence of 0.9% cholate, type I enzyme Bos taurus
3.1.3.56 52000
-
 gel filtration in presence of 0.9% cholate, type II enzyme Bos taurus
3.1.3.56 115000
-
 gel filtration without cholate, type II enzyme Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Bos taurus
-
 D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Bos taurus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.56 partial purification of membrane bound and soluble enzyme Bos taurus
3.1.3.56 type I enzyme Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 brain
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.56 25
-
 purified type I enzyme, pH 7.4, 37°C Bos taurus

Storage Stability

EC Number Storage Stability Organism
3.1.3.56 -80°C Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O substrate for type I but not type II enzyme Bos taurus D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Bos taurus D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Bos taurus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Bos taurus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?