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Literature summary extracted from

  • Niiro, N.; Koga, Y.; Ikebe, M.
    Agonist-induced changes in the phosphorylation of the myosin-binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle (2003), Biochem. J., 369, 117-128.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.53 myosin-binding subunit of MLCP is cloned and expressed in SF9 cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.53 additional information phosphorylation of the myosin-binding subunit of MLCP at Thr-641 inhibits MLCP activity Oryctolagus cuniculus
3.1.3.53 phospho-CPI-17 MLCP inhibitor protein, phosphorylation at Thr-38 of CPI-17 results in inhibition of MLCP activity; Rho kinase and protein kinase C phosphorylate CPI-17 at Thr-38, CPI-17 phosphorylation plays a role in MLCP regulation Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.53 additional information Oryctolagus cuniculus involved in the regulation of smooth muscle contraction, regulation of the MLCP activity ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.53 Oryctolagus cuniculus
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 New Zealand White rabbits, MLCP
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3.1.3.53 Rattus norvegicus
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 myosin-binding subunit of MLCP
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.53 phosphoprotein phosphorylation of the myosin-binding subunit of MLCP at the inhibitory site Thr-641 inhibits MLCP activity, but may not play a significant role in a mechanism for MLCP regulation, Rho kinase phosphorylates Thr-799, but not Thr-641 Oryctolagus cuniculus
3.1.3.53 phosphoprotein myosin-binding subunit of MLCP is phosphorylated at Thr-641 and Thr-799 by Rho kinase to 2 mol phosphate/mol of MBS Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.53 recombinant myosin-binding subunit of MLCP, expressed in SF9 cells Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.53 smooth muscle from femoral arteries Oryctolagus cuniculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.53 additional information
-
 Rattus norvegicus ?
-
 ?
3.1.3.53 additional information regulation of the MLCP activity Oryctolagus cuniculus ?
-
 ?
3.1.3.53 additional information involved in the regulation of smooth muscle contraction, regulation of the MLCP activity Oryctolagus cuniculus ?
-
 ?
3.1.3.53 myosin light-chain phosphate + H2O
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 Oryctolagus cuniculus myosin light-chain + phosphate
-
 ?