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Literature summary extracted from

  • Muranyi, A.; Erdodi, F.; Ito, M.; Gergely, P.; Hartshorne, D.J.
    Identification and localization of myosin phosphatase in human platelets (1998), Biochem. J., 330, 225-231.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.53 okadaic acid at 1 nM almost complete inhibition of PP-2A Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.53 cytoskeleton platelet, only PP-1, not PP-2A Homo sapiens 5856
-
3.1.3.53 additional information localization of PP-1 and PP-2A and their subunits in platelets Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.53 additional information Homo sapiens plays a key role in platelet function ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.53 Homo sapiens
-
 PP-1 and PP-2A
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.53 platelet from venous blood, myosin phosphatase in platelets is composed of the catalytic subunit of PP-1 plus a subunit similar to the 130 kDa regulatory myosin-binding subunit of the smooth muscle phosphatase, major phosphatase is PP-1, also PP-2A Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.53 additional information plays a key role in platelet function Homo sapiens ?
-
 ?
3.1.3.53 myosin light-chain phosphate + H2O 20 kDa myosin light chain Homo sapiens myosin light-chain + phosphate
-
 ?
3.1.3.53 phosphorylated phoshorylase A + H2O
-
 Homo sapiens phosphorylase A + phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.53 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.53 7.4
-
 assay at Homo sapiens