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Literature summary extracted from
- Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1) (2002), J. Cell. Biochem., 86, 540-552.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.26.10 | HP-RNase antibody | - |
Homo sapiens | |
| 3.1.26.10 | placental RNase inhibitor | - |
Homo sapiens | |
| 4.6.1.18 | HP-RNase antibodies | affinity purified polyclonal antibodies against human pancreatic RNase. 94% inhibition with 50 ng | Homo sapiens | |
| 4.6.1.18 | inhibit-Ace | 86% inhibition at 6 U/ml | Homo sapiens | |
| 4.6.1.18 | ribonuclease inhibitor | RI, 97% inhibition at 6 U/ml | Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.26.10 | 18000 | 26000 | molecular heterogeneity due to different degrees of N-glycosylation, SDS-PAGE | Homo sapiens |
| 4.6.1.18 | 18000 | 26000 | gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.26.10 | Homo sapiens | - |
human | - |
| 4.6.1.18 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 4.6.1.18 | glycoprotein | different degrees of glycosylation. The N-glycosylation generates the molecular heterogeneity | Homo sapiens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.26.10 | - |
Homo sapiens |
| 4.6.1.18 | gel filtration on SP-Sepharose column | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.26.10 | artery | - |
Homo sapiens | - |
| 3.1.26.10 | EAhy 926 cell | - |
Homo sapiens | - |
| 3.1.26.10 | endothelium | immortalized umbilical vein endothelial cells EaHy 926 | Homo sapiens | - |
| 3.1.26.10 | HPEC cell | - |
Homo sapiens | - |
| 3.1.26.10 | HuMMEC cell | - |
Homo sapiens | - |
| 3.1.26.10 | HUVEC cell | - |
Homo sapiens | - |
| 3.1.26.10 | lung cell line | HuLEC cell | Homo sapiens | - |
| 3.1.26.10 | placenta | - |
Homo sapiens | - |
| 4.6.1.18 | umbilical vein endothelium | primary culture, HUVEC | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.26.10 | additional information | endowed with non-digestive functions and involved in vascular homeostasis | Homo sapiens | ? | - |
? | |
| 3.1.26.10 | synthetic homopolynucleotide + H2O | acts on poly(U) and poly(C) with a higher affinity for the latter | Homo sapiens | ? | - |
? | |
| 4.6.1.18 | poly(C) + H2O | 35 times more active than with poly(U) | Homo sapiens | 3'-CMP + 3'-phosphooligonucleotides | - |
? | |
| 4.6.1.18 | poly(U) + H2O | - |
Homo sapiens | 3'-UMP + 3'-oligonucleotides | - |
? | |
| 4.6.1.18 | RNA + H2O | wheat germ RNA | Homo sapiens | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.26.10 | EC-RNase | - |
Homo sapiens |
| 3.1.26.10 | pancreatic-type ribonuclease | - |
Homo sapiens |
| 3.1.26.10 | RNase 1 | - |
Homo sapiens |
| 4.6.1.18 | EC-RNase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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