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Literature summary extracted from

  • Garras, A.; Elholm, M.; Sleboda, J.; Froyland, L.; Osmundsen, H.; Berge, R.K.
    On the effects of thia fatty acid analogs on hydrolases involved in the degradation of metabolizable and non-metabolizable acyl-CoA esters (1997), Xenobiotica, 27, 781-799.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.2 (tetradecylsulfanyl)acetic acid stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview Rattus norvegicus
3.1.2.2 3-(tetradecylsulfanyl)propanoic acid stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview Rattus norvegicus
3.1.2.2 additional information no stimulation by tetradecylthiopropionate Rattus norvegicus
3.1.2.20 (tetradecylsulfanyl)acetic acid stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview Rattus norvegicus
3.1.2.20 3-(tetradecylsulfanyl)propanoic acid stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview Rattus norvegicus
3.1.2.20 additional information no stimulation by tetradecylthiopropionate Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.2 2,2'-(decane-1,10-diyldisulfanediyl)diacetic acid palmitoyl-CoA hydrolase activity, L-fraction and peroxisomes, especially of 3-thia fatty acids treated rats Rattus norvegicus
3.1.2.20 2,2'-(decane-1,10-diyldisulfanediyl)diacetic acid palmitoyl-CoA hydrolase activity, L-fraction and peroxisomes, especially of 3-thia fatty acids treated rats Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.2 lysosome
-
 Rattus norvegicus 5764
-
3.1.2.2 microsome
-
 Rattus norvegicus
-
-
3.1.2.2 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.2 additional information substrate specificities in different subcellular fractions Rattus norvegicus
-
-
3.1.2.2 peroxisome
-
 Rattus norvegicus 5777
-
3.1.2.20 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.20 lysosome
-
 Rattus norvegicus 5764
-
3.1.2.20 microsome
-
 Rattus norvegicus
-
-
3.1.2.20 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.20 additional information substrate specificities in different subcellular fractions Rattus norvegicus
-
-
3.1.2.20 peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 hexadecanoyl-CoA + H2O Rattus norvegicus i.e. palmitoyl-CoA CoA + hexadecanoate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O Rattus norvegicus i.e. palmitoyl-CoA CoA + hexadecanoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Rattus norvegicus
-
-
-
3.1.2.20 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 liver of rats treated with 3-thia fatty acids, i.e. tetradecylthioacetic acid and 3-dithiacarboxylic acid Rattus norvegicus
-
3.1.2.20 liver of rats treated with 3-thia fatty acids, i.e. tetradecylthioacetic acid and 3-dithiacarboxylic acid Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.2 additional information
-
 activities in different subcellular fractions with different substrates after induction with 3-thia fatty acids, overview Rattus norvegicus
3.1.2.2 0.039
-
 post-nuclear fraction, substrate tetradecylthiopropionyl-CoA Rattus norvegicus
3.1.2.2 0.044
-
 post-nuclear fraction, substrate palmitoyl-CoA Rattus norvegicus
3.1.2.2 0.057
-
 post-nuclear fraction, substrate tetradecylthioacetyl-CoA Rattus norvegicus
3.1.2.20 additional information
-
 activities in different subcellular fractions with different substrates after induction with 3-thia fatty acids, overview Rattus norvegicus
3.1.2.20 0.039
-
 post-nuclear fraction, substrate tetradecylthiopropionyl-CoA Rattus norvegicus
3.1.2.20 0.044
-
 post-nuclear fraction, substrate palmitoyl-CoA Rattus norvegicus
3.1.2.20 0.057
-
 post-nuclear fraction, substrate tetradecylthioacetyl-CoA Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O
-
 Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
3.1.2.2 tetradecylthioacetyl-CoA + H2O best substrate Rattus norvegicus CoA + tetradecylthioacetate
-
 ?
3.1.2.2 tetradecylthiopropionyl-CoA + H2O
-
 Rattus norvegicus CoA + tetradecylthiopropionate
-
 ?
3.1.2.20 acyl-CoA + H2O
-
 Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
3.1.2.20 tetradecylthioacetyl-CoA + H2O best substrate Rattus norvegicus CoA + tetradecylthioacetate
-
 ?
3.1.2.20 tetradecylthiopropionyl-CoA + H2O
-
 Rattus norvegicus CoA + tetradecylthiopropionate
-
 ?