EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.2.18 | additional information | cold acclimation induces enzyme activity | Mesocricetus auratus | |
3.1.2.18 | additional information | no activation by ATP or AMP | Mesocricetus auratus | |
3.1.2.19 | additional information | cold acclimation induces enzyme activity | Mesocricetus auratus | |
3.1.2.19 | additional information | no activation by ATP or AMP | Mesocricetus auratus |
EC Number | General Stability | Organism |
---|---|---|
3.1.2.18 | ADP stabilizes | Mesocricetus auratus |
3.1.2.19 | ADP stabilizes | Mesocricetus auratus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.2.18 | AMP | inhibitory at high concentration | Mesocricetus auratus | |
3.1.2.18 | ATP | inhibitory at high concentration | Mesocricetus auratus | |
3.1.2.18 | beta-NADH | stereospecific: not alpha-NADH, reversible by ADP or Ca2+, not by Mg2+ | Mesocricetus auratus | |
3.1.2.18 | Cd2+ | - |
Mesocricetus auratus | |
3.1.2.18 | additional information | no inhibition by alpha-NADH, NADPH, NAD+, EDTA or EGTA | Mesocricetus auratus | |
3.1.2.18 | Ni2+ | - |
Mesocricetus auratus | |
3.1.2.19 | AMP | inhibitory at high concentration | Mesocricetus auratus | |
3.1.2.19 | ATP | inhibitory at high concentration | Mesocricetus auratus | |
3.1.2.19 | beta-NADH | stereospecific: not alpha-NADH, reversible by ADP or Ca2+, not by Mg2+ | Mesocricetus auratus | |
3.1.2.19 | Cd2+ | - |
Mesocricetus auratus | |
3.1.2.19 | additional information | no inhibition by alpha-NADH, NADPH, NAD+, EDTA or EGTA | Mesocricetus auratus | |
3.1.2.19 | Ni2+ | - |
Mesocricetus auratus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.2.18 | 0.013 | - |
ADP | pH 7.4, 25°C | Mesocricetus auratus | |
3.1.2.18 | 0.3 | - |
Ca2+ | pH 7.4, 25°C | Mesocricetus auratus | |
3.1.2.19 | 0.013 | - |
ADP | pH 7.4, 25°C | Mesocricetus auratus | |
3.1.2.19 | 0.3 | - |
Ca2+ | pH 7.4, 25°C | Mesocricetus auratus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.2.18 | mitochondrial matrix | submitochondrial distribution | Mesocricetus auratus | 5759 | - |
3.1.2.18 | mitochondrion | - |
Mesocricetus auratus | 5739 | - |
3.1.2.18 | additional information | submitochondrial and subcellular distribution | Mesocricetus auratus | - |
- |
3.1.2.19 | mitochondrial matrix | - |
Mesocricetus auratus | 5759 | - |
3.1.2.19 | additional information | submitochondrial and subcellular distribution | Mesocricetus auratus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.2.18 | Ca2+ | activation, Km-value: 0.3 mM | Mesocricetus auratus | |
3.1.2.18 | K+ | activation | Mesocricetus auratus | |
3.1.2.18 | Mg2+ | activation | Mesocricetus auratus | |
3.1.2.18 | additional information | no activation by Na+ | Mesocricetus auratus | |
3.1.2.19 | Ba2+ | activation | Mesocricetus auratus | |
3.1.2.19 | Ca2+ | activation | Mesocricetus auratus | |
3.1.2.19 | K+ | activation, 0.2 M | Mesocricetus auratus | |
3.1.2.19 | Li+ | activation | Mesocricetus auratus | |
3.1.2.19 | Mg2+ | activation | Mesocricetus auratus | |
3.1.2.19 | additional information | no activation by Na+ | Mesocricetus auratus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.2.18 | acyl-CoA + H2O | Mesocricetus auratus | - |
CoA + a carboxylate | - |
? | |
3.1.2.19 | acyl-CoA + H2O | Mesocricetus auratus | - |
CoA + a carboxylate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.2.18 | Mesocricetus auratus | - |
Syrian hamster, adult female, acclimated to cold | - |
3.1.2.19 | Mesocricetus auratus | - |
Syrian hamster, adult female, acclimated to cold | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.2.18 | brown adipose tissue | - |
Mesocricetus auratus | - |
3.1.2.18 | additional information | not in liver tissue | Mesocricetus auratus | - |
3.1.2.19 | brown adipose tissue | - |
Mesocricetus auratus | - |
3.1.2.19 | additional information | not in liver tissue | Mesocricetus auratus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.1.2.19 | 0.11 | - |
mitochondria | Mesocricetus auratus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.2.18 | acyl-CoA + H2O | - |
Mesocricetus auratus | CoA + a carboxylate | - |
? | |
3.1.2.18 | malonyl-CoA + H2O | very poor substrate | Mesocricetus auratus | malonate + CoA | - |
? | |
3.1.2.18 | propionyl-CoA + H2O | best substrate | Mesocricetus auratus | CoA + propionate | - |
? | |
3.1.2.19 | acyl-CoA + H2O | - |
Mesocricetus auratus | CoA + a carboxylate | - |
? | |
3.1.2.19 | malonyl-CoA + H2O | very poor substrate | Mesocricetus auratus | malonate + CoA | - |
? | |
3.1.2.19 | additional information | broad substrate spectrum, substrate specificity | Mesocricetus auratus | ? | - |
? | |
3.1.2.19 | nonanoyl-CoA + H2O | best substrate | Mesocricetus auratus | CoA + nonanoate | - |
? | |
3.1.2.19 | octanoyl-CoA + H2O | - |
Mesocricetus auratus | CoA + octanoate | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.1.2.18 | 25 | - |
assay at | Mesocricetus auratus |
3.1.2.19 | 25 | - |
assay at | Mesocricetus auratus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.1.2.18 | 25 | - |
t1/2: 1 min, in buffer with Triton X-100 but without substrates, decrease of activity in intact mitochondria, ADP stabilizes: t1/2: 1 h, substrates protect | Mesocricetus auratus |
3.1.2.19 | 25 | - |
t1/2: 1 min, in buffer with Triton X-100 but without substrates, decrease of activity in intact mitochondria, ADP stabilizes: t1/2: 1 h, substrates protect | Mesocricetus auratus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.2.18 | 7.4 | - |
assay at | Mesocricetus auratus |
3.1.2.19 | 7.4 | - |
assay at | Mesocricetus auratus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
3.1.2.18 | ADP | requirement | Mesocricetus auratus | |
3.1.2.19 | ADP | requirement | Mesocricetus auratus |