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Literature summary extracted from

  • Alexson, S.E.H.; Nedergard, J.
    A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria (1988), J. Biol. Chem., 263, 13564-13571.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.18 additional information cold acclimation induces enzyme activity Mesocricetus auratus
3.1.2.18 additional information no activation by ATP or AMP Mesocricetus auratus
3.1.2.19 additional information cold acclimation induces enzyme activity Mesocricetus auratus
3.1.2.19 additional information no activation by ATP or AMP Mesocricetus auratus

General Stability

EC Number General Stability Organism
3.1.2.18 ADP stabilizes Mesocricetus auratus
3.1.2.19 ADP stabilizes Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.18 AMP inhibitory at high concentration Mesocricetus auratus
3.1.2.18 ATP inhibitory at high concentration Mesocricetus auratus
3.1.2.18 beta-NADH stereospecific: not alpha-NADH, reversible by ADP or Ca2+, not by Mg2+ Mesocricetus auratus
3.1.2.18 Cd2+
-
Mesocricetus auratus
3.1.2.18 additional information no inhibition by alpha-NADH, NADPH, NAD+, EDTA or EGTA Mesocricetus auratus
3.1.2.18 Ni2+
-
Mesocricetus auratus
3.1.2.19 AMP inhibitory at high concentration Mesocricetus auratus
3.1.2.19 ATP inhibitory at high concentration Mesocricetus auratus
3.1.2.19 beta-NADH stereospecific: not alpha-NADH, reversible by ADP or Ca2+, not by Mg2+ Mesocricetus auratus
3.1.2.19 Cd2+
-
Mesocricetus auratus
3.1.2.19 additional information no inhibition by alpha-NADH, NADPH, NAD+, EDTA or EGTA Mesocricetus auratus
3.1.2.19 Ni2+
-
Mesocricetus auratus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.18 0.013
-
ADP pH 7.4, 25°C Mesocricetus auratus
3.1.2.18 0.3
-
Ca2+ pH 7.4, 25°C Mesocricetus auratus
3.1.2.19 0.013
-
ADP pH 7.4, 25°C Mesocricetus auratus
3.1.2.19 0.3
-
Ca2+ pH 7.4, 25°C Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.18 mitochondrial matrix submitochondrial distribution Mesocricetus auratus 5759
-
3.1.2.18 mitochondrion
-
Mesocricetus auratus 5739
-
3.1.2.18 additional information submitochondrial and subcellular distribution Mesocricetus auratus
-
-
3.1.2.19 mitochondrial matrix
-
Mesocricetus auratus 5759
-
3.1.2.19 additional information submitochondrial and subcellular distribution Mesocricetus auratus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.2.18 Ca2+ activation, Km-value: 0.3 mM Mesocricetus auratus
3.1.2.18 K+ activation Mesocricetus auratus
3.1.2.18 Mg2+ activation Mesocricetus auratus
3.1.2.18 additional information no activation by Na+ Mesocricetus auratus
3.1.2.19 Ba2+ activation Mesocricetus auratus
3.1.2.19 Ca2+ activation Mesocricetus auratus
3.1.2.19 K+ activation, 0.2 M Mesocricetus auratus
3.1.2.19 Li+ activation Mesocricetus auratus
3.1.2.19 Mg2+ activation Mesocricetus auratus
3.1.2.19 additional information no activation by Na+ Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.18 acyl-CoA + H2O Mesocricetus auratus
-
CoA + a carboxylate
-
?
3.1.2.19 acyl-CoA + H2O Mesocricetus auratus
-
CoA + a carboxylate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.18 Mesocricetus auratus
-
Syrian hamster, adult female, acclimated to cold
-
3.1.2.19 Mesocricetus auratus
-
Syrian hamster, adult female, acclimated to cold
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.18 brown adipose tissue
-
Mesocricetus auratus
-
3.1.2.18 additional information not in liver tissue Mesocricetus auratus
-
3.1.2.19 brown adipose tissue
-
Mesocricetus auratus
-
3.1.2.19 additional information not in liver tissue Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.19 0.11
-
mitochondria Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.18 acyl-CoA + H2O
-
Mesocricetus auratus CoA + a carboxylate
-
?
3.1.2.18 malonyl-CoA + H2O very poor substrate Mesocricetus auratus malonate + CoA
-
?
3.1.2.18 propionyl-CoA + H2O best substrate Mesocricetus auratus CoA + propionate
-
?
3.1.2.19 acyl-CoA + H2O
-
Mesocricetus auratus CoA + a carboxylate
-
?
3.1.2.19 malonyl-CoA + H2O very poor substrate Mesocricetus auratus malonate + CoA
-
?
3.1.2.19 additional information broad substrate spectrum, substrate specificity Mesocricetus auratus ?
-
?
3.1.2.19 nonanoyl-CoA + H2O best substrate Mesocricetus auratus CoA + nonanoate
-
?
3.1.2.19 octanoyl-CoA + H2O
-
Mesocricetus auratus CoA + octanoate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.2.18 25
-
assay at Mesocricetus auratus
3.1.2.19 25
-
assay at Mesocricetus auratus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.2.18 25
-
t1/2: 1 min, in buffer with Triton X-100 but without substrates, decrease of activity in intact mitochondria, ADP stabilizes: t1/2: 1 h, substrates protect Mesocricetus auratus
3.1.2.19 25
-
t1/2: 1 min, in buffer with Triton X-100 but without substrates, decrease of activity in intact mitochondria, ADP stabilizes: t1/2: 1 h, substrates protect Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.18 7.4
-
assay at Mesocricetus auratus
3.1.2.19 7.4
-
assay at Mesocricetus auratus

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.2.18 ADP requirement Mesocricetus auratus
3.1.2.19 ADP requirement Mesocricetus auratus