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Literature summary extracted from

  • Kaphalia, B.S.; Green, S.M.; Ansari, G.A.S.
    Fatty acid ethyl and methyl ester synthases, and fatty acid anilide synthase in HepG2 and AR42J cells: Interrelationships and inhibition by tri-o-tolyl phosphate (1999), Toxicol. Appl. Pharmacol., 159, 134-141.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.67 additional information no inhibition of FAEE, FAME or fatty acid anilide synthesizing activities in AR42J cells by tri-o-tolyl phosphate Rattus norvegicus
3.1.1.67 tri-o-tolyl phosphate 0.0025 mM, 86-90% inhibition, Hep-G2 cells Homo sapiens
3.1.1.67 tri-o-tolyl phosphate
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.67 Homo sapiens
-
-
-
3.1.1.67 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.67 AR42J cell rat pancreatic tumor cell line Rattus norvegicus
-
3.1.1.67 Hep-G2 cell human hepatoblastoma cell line Homo sapiens
-
3.1.1.67 additional information the enzyme responsible for FAEE, FAME or fatty acid anilide synthesizing activities is most probably carboxylesterase in Hep-G2 cells and is structurally and functionally different from that present in AR42J cells, i.e. hepatic FAEES is structurally and functionally different from that of pancreas Homo sapiens
-
3.1.1.67 additional information the enzyme responsible for FAEE, FAME or fatty acid anilide synthesizing activities is most probably carboxylesterase in Hep-G2 cells and is structurally and functionally different from that present in AR42J cells, i.e. hepatic FAEES is structurally and functionally different from that of pancreas Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.67 fatty acid + ethanol
-
 Homo sapiens fatty acyl ethyl ester + H2O
-
 ?
3.1.1.67 fatty acid + ethanol
-
 Rattus norvegicus fatty acyl ethyl ester + H2O
-
 ?
3.1.1.67 additional information
-
 Rattus norvegicus ?
-
 ?
3.1.1.67 additional information the enzyme responsible for the fatty acid ethyl ester, fatty acid methyl ester or fatty acid anilide synthesizing activities is most probably carboxylesterase in Hep-G2 cells Homo sapiens ?
-
 ?
3.1.1.67 oleate + aniline methanol is a better substrate than ethanol and aniline Homo sapiens oleyl anilide + H2O
-
 ?
3.1.1.67 oleate + aniline methanol is a better substrate than ethanol and aniline Rattus norvegicus oleyl anilide + H2O
-
 ?
3.1.1.67 oleate + ethanol methanol is a better substrate than ethanol and aniline Homo sapiens ethyl oleate + H2O
-
 ?
3.1.1.67 oleate + ethanol methanol is a better substrate than ethanol and aniline Rattus norvegicus ethyl oleate + H2O
-
 ?
3.1.1.67 oleate + methanol methanol is a better substrate than ethanol and aniline Homo sapiens methyl oleate + H2O
-
 ?
3.1.1.67 oleate + methanol methanol is a better substrate than ethanol and aniline Rattus norvegicus methyl oleate + H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.67 37
-
 assay at Homo sapiens
3.1.1.67 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.67 7.4
-
 assay at Homo sapiens
3.1.1.67 7.4
-
 assay at Rattus norvegicus