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Literature summary extracted from

  • Heith, A.M.; Morse, C.R.; Tsujita, T.; Volpacelli, S.A.; Flood, J.G.; Laposata, M.
    Fatty acid ethyl ester synthase catalyzes the esterification of ethanol to cocaine (1995), Biochem. Biophys. Res. Commun., 208, 549-554.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.67 medicine enzyme is responsible for the formation of fatty acid ethyl esters, which are mediators of ethanol-induced organ damage Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.67 cocaine + ethanol Homo sapiens enzyme may be responsible for a portion of cocaethylene synthesis in vivo cocaethylene + methanol product enhances cocaine toxicity ?
3.1.1.67 fatty acid + ethanol Homo sapiens enzyme is present selectively in the organs damaged by ethanol abuse fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.67 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.67
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.67 duodenum only FAEES activity, no cocaethylene synthase activity Homo sapiens
-
3.1.1.67 lung
-
 Homo sapiens
-
3.1.1.67 muscle
-
 Homo sapiens
-
3.1.1.67 spleen
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.67 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.67 cocaine + ethanol
-
 Homo sapiens cocaethylene + methanol
-
 ?
3.1.1.67 cocaine + ethanol enzyme may be responsible for a portion of cocaethylene synthesis in vivo Homo sapiens cocaethylene + methanol product enhances cocaine toxicity ?
3.1.1.67 fatty acid + ethanol
-
 Homo sapiens fatty acyl ethyl ester + H2O
-
 ?
3.1.1.67 fatty acid + ethanol enzyme is present selectively in the organs damaged by ethanol abuse Homo sapiens fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?
3.1.1.67 oleate + ethanol
-
 Homo sapiens ethyl oleate + H2O
-
 ?
3.1.1.67 p-nitrophenyl butyrate + H2O hydrolysis Homo sapiens butyrate + p-nitrophenol
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.67 37
-
 assay at Homo sapiens