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Literature summary extracted from

  • Varki, A.; Muchmore, E.; Diaz, S.
    A sialic acid-specific O-acetylesterase in human erythrocytes: possible identity with esterase D, the genetic marker of retinoblastomas and Wilson disease (1986), Proc. Natl. Acad. Sci. USA, 83, 882-886.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.56 Dansylglutamylglycylarginyl chloromethyl ketone weak Homo sapiens
3.1.1.56 diisopropyl fluorophosphate
-
 Homo sapiens
3.1.1.56 F-
-
 Homo sapiens
3.1.1.56 HgCl2
-
 Homo sapiens
3.1.1.56 iodoacetamide weak Homo sapiens
3.1.1.56 PCMB
-
 Homo sapiens
3.1.1.56 phenylmethylsulfonyl fluoride
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.56 4-methylumbelliferyl acetate + H2O Homo sapiens esterase D is identical to sialic acid-specific O-acetylesterase, which appears to be involved in the recycling of O-acetylated sialic acid molecules 4-methylumbelliferone + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.56 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.56 partial, esterase D is identical to sialic acid-specific O-acetylesterase Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.56 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.56 4-methylumbelliferyl acetate + H2O
-
 Homo sapiens 4-methylumbelliferone + acetate
-
 ?
3.1.1.56 4-methylumbelliferyl acetate + H2O esterase D is identical to sialic acid-specific O-acetylesterase, which appears to be involved in the recycling of O-acetylated sialic acid molecules Homo sapiens 4-methylumbelliferone + acetate
-
 ?
3.1.1.56 4-nitrophenyl acetate + H2O
-
 Homo sapiens 4-nitrophenol + acetate
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.1.56 40
-
 15 min, about 25% loss of activity Homo sapiens
3.1.1.56 50
-
 15 min, about 40% loss of activity Homo sapiens
3.1.1.56 70
-
 15 min, about 75% loss of activity Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.1.56 5 9.5 pH 5: about 40% of activity maximum, pH 9.5: about 30% of activity maximum Homo sapiens