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Literature summary extracted from

  • Benedito, M.A.
    Fluorimetric determination of tissue distribution and differences between the activity of aspirin esterases I and II in mice and rats (1997), J. Pharm. Pharmacol., 49, 273-276.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.55 1.33
-
 Acetyl salicylate pH 7.4, 37°C, isozyme I Rattus norvegicus
3.1.1.55 8.85
-
 Acetyl salicylate pH 5.5, 37°C, isozyme II Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.55 acetyl salicylate + H2O Mus musculus i.e. aspirin salicylate + acetate
-
 ?
3.1.1.55 acetyl salicylate + H2O Rattus norvegicus i.e. aspirin salicylate + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.55 Mus musculus
-
 2 isozymes I and II
-
3.1.1.55 Rattus norvegicus
-
 2 isozymes I and II
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.55 adrenal gland only isozyme II Rattus norvegicus
-
3.1.1.55 brain
-
 Rattus norvegicus
-
3.1.1.55 kidney
-
 Mus musculus
-
3.1.1.55 kidney
-
 Rattus norvegicus
-
3.1.1.55 liver
-
 Mus musculus
-
3.1.1.55 liver
-
 Rattus norvegicus
-
3.1.1.55 plasma only isozyme II Rattus norvegicus
-
3.1.1.55 serum
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.55 0.025
-
 isozyme I, kidney Mus musculus
3.1.1.55 0.035
-
 isozyme II, kidney Rattus norvegicus
3.1.1.55 0.036
-
 isozyme I, kidney Rattus norvegicus
3.1.1.55 0.0385
-
 isozyme I, liver Mus musculus
3.1.1.55 0.041
-
 isozyme II, liver Rattus norvegicus
3.1.1.55 0.049
-
 isozyme I, liver Rattus norvegicus
3.1.1.55 0.077
-
 isozyme II, liver Mus musculus
3.1.1.55 0.08
-
 isozyme II, kidney Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.55 acetyl salicylate + H2O i.e. aspirin Mus musculus salicylate + acetate
-
 ?
3.1.1.55 acetyl salicylate + H2O i.e. aspirin Rattus norvegicus salicylate + acetate
-
 ?
3.1.1.55 acetylsalicylate + H2O i.e. aspirin Mus musculus salicylate + acetate
-
 ?
3.1.1.55 acetylsalicylate + H2O i.e. aspirin Rattus norvegicus salicylate + acetate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.55 37
-
 assay at Mus musculus
3.1.1.55 37
-
 assay at Rattus norvegicus
3.1.1.55 37
-
 isozyme I and II Mus musculus
3.1.1.55 37
-
 isozyme I and II Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.55 5.5
-
 isozyme II, assay at Mus musculus
3.1.1.55 5.5
-
 isozyme II, assay at Rattus norvegicus
3.1.1.55 7.4
-
 isozyme I, assay at Mus musculus
3.1.1.55 7.4
-
 isozyme I, assay at Rattus norvegicus