BRENDA - Enzyme Database show

Biochemistry and reproductive endocrinology of estrogen sulfotransferase

Song, W.C.; Ann. N. Y. Acad. Sci. 948, 43-50 (2001)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.8.2.4
-
Homo sapiens
Crystallization (Commentary)
EC Number
Crystallization
Organism
2.8.2.4
-
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.4
4,4'-(hydroxy)2-3,5,'3',5'-tetrachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-2,3,5,2',3',4',5'-heptachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-3,5,2',3',4'-pentachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-3,5,3',4',5'-pentachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-3,5,3',4'-tetrachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-3,5,3',5'-tetrachlorobiphenyl
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.2.4
0.000025
-
estradiol
-
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.4
cytosol
-
Cavia porcellus
5829
-
2.8.2.4
cytosol
-
Rattus norvegicus
5829
-
2.8.2.4
cytosol
-
Homo sapiens
5829
-
2.8.2.4
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
Cavia porcellus
-
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
Cavia porcellus
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
Mus musculus
enzyme does not distinguish between estradiol and estrone, both appear to be natural substrates
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Cavia porcellus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Cavia porcellus
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Homo sapiens
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Bos taurus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Bos taurus
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.4
Bos taurus
-
-
-
2.8.2.4
Cavia porcellus
-
guinea pig
-
2.8.2.4
Homo sapiens
-
human
-
2.8.2.4
Mus musculus
-
mouse
-
2.8.2.4
Rattus norvegicus
-
rat
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
adrenal gland
-
Bos taurus
-
2.8.2.4
adrenal gland
-
Cavia porcellus
-
2.8.2.4
epithelium
mammary epithelial cells; not expressed in a host of breast cancer cell lines such as MCF-7 cells
Homo sapiens
-
2.8.2.4
placenta
-
Bos taurus
-
2.8.2.4
placenta
-
Homo sapiens
-
2.8.2.4
placenta
-
Mus musculus
-
2.8.2.4
testis
-
Cavia porcellus
-
2.8.2.4
testis
-
Homo sapiens
-
2.8.2.4
testis
localized exclusively to Leydig cells
Mus musculus
-
2.8.2.4
testis
-
Rattus norvegicus
-
2.8.2.4
uterus
-
Cavia porcellus
-
2.8.2.4
uterus
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
645906
Mus musculus
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
645906
Mus musculus
r
2.8.2.4
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
645906
Homo sapiens
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
645906
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
-
645906
Cavia porcellus
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
645906
Cavia porcellus
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
-
645906
Mus musculus
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
-
645906
Homo sapiens
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
645906
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
enzyme does not distinguish between estradiol and estrone, both appear to be natural substrates
645906
Mus musculus
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645906
Cavia porcellus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645906
Cavia porcellus
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645906
Homo sapiens
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645906
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645906
Rattus norvegicus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645906
Rattus norvegicus
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645906
Bos taurus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645906
Bos taurus
r
2.8.2.4
additional information
very little reactivity toward hydroxysteroids such as dehydroepiandrosterone
645906
Mus musculus
?
-
-
-
-
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.2.4
-
Homo sapiens
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
2.8.2.4
-
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.4
4,4'-(hydroxy)2-3,5,'3',5'-tetrachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-2,3,5,2',3',4',5'-heptachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-3,5,2',3',4'-pentachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-3,5,3',4',5'-pentachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-3,5,3',4'-tetrachlorobiphenyl
-
Homo sapiens
2.8.2.4
4-hydroxy-3,5,3',5'-tetrachlorobiphenyl
-
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.2.4
0.000025
-
estradiol
-
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.4
cytosol
-
Cavia porcellus
5829
-
2.8.2.4
cytosol
-
Rattus norvegicus
5829
-
2.8.2.4
cytosol
-
Mus musculus
5829
-
2.8.2.4
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
Cavia porcellus
-
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
Cavia porcellus
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
Mus musculus
enzyme does not distinguish between estradiol and estrone, both appear to be natural substrates
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Cavia porcellus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Cavia porcellus
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Homo sapiens
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Bos taurus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Bos taurus
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
adrenal gland
-
Bos taurus
-
2.8.2.4
adrenal gland
-
Cavia porcellus
-
2.8.2.4
epithelium
mammary epithelial cells; not expressed in a host of breast cancer cell lines such as MCF-7 cells
Homo sapiens
-
2.8.2.4
placenta
-
Bos taurus
-
2.8.2.4
placenta
-
Homo sapiens
-
2.8.2.4
placenta
-
Mus musculus
-
2.8.2.4
testis
-
Cavia porcellus
-
2.8.2.4
testis
-
Homo sapiens
-
2.8.2.4
testis
localized exclusively to Leydig cells
Mus musculus
-
2.8.2.4
testis
-
Rattus norvegicus
-
2.8.2.4
uterus
-
Cavia porcellus
-
2.8.2.4
uterus
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
645906
Mus musculus
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
645906
Mus musculus
r
2.8.2.4
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
645906
Homo sapiens
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
645906
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
-
645906
Cavia porcellus
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
645906
Cavia porcellus
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
-
645906
Mus musculus
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
-
645906
Homo sapiens
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
645906
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estradiol
enzyme does not distinguish between estradiol and estrone, both appear to be natural substrates
645906
Mus musculus
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645906
Cavia porcellus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645906
Cavia porcellus
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645906
Homo sapiens
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645906
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645906
Rattus norvegicus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645906
Rattus norvegicus
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645906
Bos taurus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645906
Bos taurus
r
2.8.2.4
additional information
very little reactivity toward hydroxysteroids such as dehydroepiandrosterone
645906
Mus musculus
?
-
-
-
-