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Literature summary extracted from

  • Rozhin, J.; Huo, A.; Zemlicka, J.; Brooks, S.C.
    Studies on bovine adrenal estrogen sulfotransferase. Inhibition and possible involvement of adenine-estrogen stacking (1977), J. Biol. Chem., 252, 7214-7220.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.4 (17beta)-3,17-dihydroxy-1,3,5(10)estatriene-6-one
-
 Bos taurus
2.8.2.4 (17beta)-3-methoxyestra-1(10),2,4-trien-17-ol
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-17beta-ol
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,16alpha,17beta-triol
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,16alpha-diol
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,16beta,17beta-triol
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,17beta-diol
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,17beta-diol 17beta-phosphate
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,17beta-diol 17beta-sulfate
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,17beta-diol 3,17beta-diphosphate
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,17beta-diol 3-phosphate
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,17beta-diol-3-acetate
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3,17beta-diol-3-benzoate
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3-ol
-
 Bos taurus
2.8.2.4 1,3,5(10)estatriene-3-ol 17-one 3-sulfate
-
 Bos taurus
2.8.2.4 1-[2-(p-[3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl]phenoxy)ethyl]-pyrrolidine hydrochloride
-
 Bos taurus
2.8.2.4 17beta-hydroxy-5alpha-androstane-3-one
-
 Bos taurus
2.8.2.4 17beta-hydroxy-5beta-androstane-3-one
-
 Bos taurus
2.8.2.4 2,4-dibromo-1,3,5(10)estatriene-3,17beta-diol
-
 Bos taurus
2.8.2.4 2,4-dinitro-1,3,5(10)estatriene-3,17beta-diol
-
 Bos taurus
2.8.2.4 2-amino-1,3,5(10)estatriene-3,17beta-diol
-
 Bos taurus
2.8.2.4 2-nitro-1,3,5(10)estatriene-3,17beta-diol
-
 Bos taurus
2.8.2.4 3-hydroxyestra-1(10),2,4-trien-17-one
-
 Bos taurus
2.8.2.4 3-methoxy-4-nitroestra-1(10),2,4-trien-17-one
-
 Bos taurus
2.8.2.4 3beta-hydroxy-5beta-androstane-17-one
-
 Bos taurus
2.8.2.4 3beta-hydroxy-androst-5-ene-17-one
-
 Bos taurus
2.8.2.4 4-amino-1,3,5(10)estatriene-3,17beta-diol
-
 Bos taurus
2.8.2.4 4-nitro-1,3,5(10)estatriene-3,17beta-diol
-
 Bos taurus
2.8.2.4 5-androstene-3beta,17beta-diol
-
 Bos taurus
2.8.2.4 5alpha-Androstane-3beta,17beta-diol
-
 Bos taurus
2.8.2.4 androst-5-ene-3beta-ol
-
 Bos taurus
2.8.2.4 diethylstilbestrol
-
 Bos taurus
2.8.2.4 additional information 5alpha-androstanes are weak competitive inhibitors, the product estrone sulfate is not inhibitory, no inhibition with 1,3,5(10)estatriene, 1,3,5,(10)estatriene-3,17beta-diol 3,17beta-disulfate, MER-25, 1-[p-2-diethylaminoethoxyphenyl]-1-phenyl-2-p-methoxyphenyl ethanol and 5-androstene Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone Bos taurus
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Bos taurus
-
 bovine
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 adrenal gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone
-
 Bos taurus adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.4 0.00011
-
 2,4-dibromo-1,3,5(10)estatriene-3,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.00015
-
 4-nitro-1,3,5(10)estatriene-3,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0013
-
 1,3,5(10)estatriene-3,16alpha-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0024
-
 2-nitro-1,3,5(10)estatriene-3,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0035
-
 1,3,5(10)estatriene-3-ol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0035
-
 2-amino-1,3,5(10)estatriene-3,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0035
-
 4-amino-1,3,5(10)estatriene-3,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0043
-
 2,4-dinitro-1,3,5(10)estatriene-3,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0043
-
 3-methoxy-4-nitroestra-1(10),2,4-trien-17-one pH 8.1, 37°C Bos taurus
2.8.2.4 0.0048
-
 (17beta)-3-methoxyestra-1(10),2,4-trien-17-ol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0049
-
 3-hydroxyestra-1(10),2,4-trien-17-one pH 8.1, 37°C Bos taurus
2.8.2.4 0.0055
-
 1,3,5(10)estatriene-3,16beta,17beta-triol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0055
-
 (17beta)-3,17-dihydroxy-1,3,5(10)estatriene-6-one pH 8.1, 37°C Bos taurus
2.8.2.4 0.0061
-
 1,3,5(10)estatriene-3,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.0082
-
 1,3,5(10)estatriene-3,16alpha,17beta-triol pH 8.1, 37°C Bos taurus
2.8.2.4 0.016
-
 1,3,5(10)estatriene-17beta-ol pH 8.1, 37°C Bos taurus
2.8.2.4 0.017
-
 1,3,5(10)estatriene-3,17beta-diol-3-acetate pH 8.1, 37°C Bos taurus
2.8.2.4 0.021
-
 1,3,5(10)estatriene-3,17beta-diol 17beta-phosphate pH 8.1, 37°C Bos taurus
2.8.2.4 0.024
-
 1,3,5(10)estatriene-3,17beta-diol 3-phosphate pH 8.1, 37°C Bos taurus
2.8.2.4 0.035
-
 5-androstene-3beta,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.038
-
 17beta-hydroxy-5alpha-androstane-3-one pH 8.1, 37°C Bos taurus
2.8.2.4 0.047
-
 5alpha-Androstane-3beta,17beta-diol pH 8.1, 37°C Bos taurus
2.8.2.4 0.047
-
 1,3,5(10)estatriene-3,17beta-diol 17beta-sulfate pH 8.1, 37°C Bos taurus
2.8.2.4 0.05
-
 androst-5-ene-3beta-ol pH 8.1, 37°C Bos taurus
2.8.2.4 0.074
-
 17beta-hydroxy-5beta-androstane-3-one pH 8.1, 37°C Bos taurus
2.8.2.4 0.074
-
 1-[2-(p-[3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl]phenoxy)ethyl]-pyrrolidine hydrochloride pH 8.1, 37°C Bos taurus
2.8.2.4 0.09
-
 1,3,5(10)estatriene-3,17beta-diol-3-benzoate pH 8.1, 37°C Bos taurus
2.8.2.4 0.12
-
 diethylstilbestrol pH 8.1, 37°C Bos taurus
2.8.2.4 0.128
-
 1,3,5(10)estatriene-3-ol-17-one 3-sulfate pH 8.1, 37°C Bos taurus
2.8.2.4 0.17
-
 3beta-hydroxy-5-androstene-17-one pH 8.1, 37°C Bos taurus
2.8.2.4 0.302
-
 3beta-hydroxy-5beta-androstane-17-one pH 8.1, 37°C Bos taurus
2.8.2.4 0.333
-
 1,3,5(10)estatriene-3,17beta-diol 3,17beta-diphosphate pH 8.1, 37°C Bos taurus