BRENDA - Enzyme Database show

Specificity studies on bovine adrenal estrogen sulfotransferase

Rozhin, J.; Soderstrom, R.L.; Brooks, S.C.; J. Biol. Chem. 249, 2079-2087 (1974)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Bos taurus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Bos taurus
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.4
Bos taurus
-
bovine
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
adrenal gland
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,16alpha,17beta-triol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien-16alpha,17beta-diol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17alpha-diol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 17alpha-ol-3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoacetate
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoglucosiduronate
very low sulfation rate
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monovalerinate
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3-ol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 11-hydroxy-1,3,5(10)-estratrien-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 16-epiestriol
1,3,5(10)estratiene-3,16beta,17beta-triol
645871
Bos taurus
adenosine 3',5'-bisphosphate + 16-epiestriol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 17alpha-ethynyl-1,3,5(10)-estratrien-3,17beta-diol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 17alpha-ethynyl-1,3,5(10)-estratrien-17beta-ol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3,16alpha-dihydroxy-1,3,5(10)-estratrien-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 16-alpha-hydroxy-1,3,5(10)-estratrien-17-one 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10),9-estratetraen-12-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10)-estratrien-6-one
high sulfation rate
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6,8-estrapentaen-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10),6,8-estrapentaen-17-one 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6-estratetraen-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10),6-estratetraen-17-one 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),7-estratetraen-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),9-estratetraen-12,17-dione
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10),9-estratetraen-12,17-dione 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10)-estratrien-16-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratriene-16-one 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 4-nitro-1,3,5(10)estratrien-3,17beta-diol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 7alpha-methyl-1,3,5(10)-estratrien-3,17beta-diol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 7alpha-methyl-1,3,5(10)-estratrien 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 7alpha-methyl-3-hydroxy-1,3,5(10)-estratrien-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645871
Bos taurus
r
2.8.2.4
additional information
enzyme does not sulfate an OH in position 2 or 4 of estrogens but sulfates, with decreased efficiency, the phenolic-OH on 6-benzoyl-naphthol, anthraquinone, fluorenes, diphenyl and tetraline, almost no sulfation of 4-hydroxybenzoic acid esters
645871
Bos taurus
?
-
-
-
-
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.8.2.4
8.1
-
-
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Bos taurus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Bos taurus
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
adrenal gland
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,16alpha,17beta-triol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien-16alpha,17beta-diol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17alpha-diol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 17alpha-ol-3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoacetate
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoglucosiduronate
very low sulfation rate
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monovalerinate
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3-ol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 11-hydroxy-1,3,5(10)-estratrien-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 16-epiestriol
1,3,5(10)estratiene-3,16beta,17beta-triol
645871
Bos taurus
adenosine 3',5'-bisphosphate + 16-epiestriol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 17alpha-ethynyl-1,3,5(10)-estratrien-3,17beta-diol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 17alpha-ethynyl-1,3,5(10)-estratrien-17beta-ol 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3,16alpha-dihydroxy-1,3,5(10)-estratrien-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 16-alpha-hydroxy-1,3,5(10)-estratrien-17-one 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10),9-estratetraen-12-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10)-estratrien-6-one
high sulfation rate
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6,8-estrapentaen-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10),6,8-estrapentaen-17-one 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6-estratetraen-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10),6-estratetraen-17-one 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),7-estratetraen-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),9-estratetraen-12,17-dione
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10),9-estratetraen-12,17-dione 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10)-estratrien-16-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratriene-16-one 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 4-nitro-1,3,5(10)estratrien-3,17beta-diol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 7alpha-methyl-1,3,5(10)-estratrien-3,17beta-diol
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + 7alpha-methyl-1,3,5(10)-estratrien 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + 7alpha-methyl-3-hydroxy-1,3,5(10)-estratrien-17-one
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + ?
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645871
Bos taurus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645871
Bos taurus
r
2.8.2.4
additional information
enzyme does not sulfate an OH in position 2 or 4 of estrogens but sulfates, with decreased efficiency, the phenolic-OH on 6-benzoyl-naphthol, anthraquinone, fluorenes, diphenyl and tetraline, almost no sulfation of 4-hydroxybenzoic acid esters
645871
Bos taurus
?
-
-
-
-
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.8.2.4
8.1
-
-
Bos taurus