BRENDA - Enzyme Database show

Enzymic synthesis of steroid sulphates. VIII. Inhibition of estrogen sulphotransferase by retinoic acid and free fatty acids

Adams, J.B.; Ellyard, R.K.; Biochim. Biophys. Acta 260, 724-730 (1972)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.4
3'-AMP
-
Bos taurus
2.8.2.4
adenosine 5'-phosphosulfate
-
Bos taurus
2.8.2.4
adenosine 5'-sulfate
-
Bos taurus
2.8.2.4
cetyltrimethylammonium bromide
-
Bos taurus
2.8.2.4
fatty acid
unsaturated fatty acid of chain length C11-C14
Bos taurus
2.8.2.4
myristate
inhibition is non-competitive with respect to the substrate estrone
Bos taurus
2.8.2.4
retinoic acid
-
Bos taurus
2.8.2.4
Sodium dodecyl sulfate
-
Bos taurus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.2.4
0.0027
-
estrone
pH 7.5, 37°C
Bos taurus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Bos taurus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Bos taurus
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.4
Bos taurus
-
bovine
-
Purification (Commentary)
EC Number
Commentary
Organism
2.8.2.4
-
Bos taurus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
adrenal gland
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645868
Bos taurus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645868
Bos taurus
r
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.8.2.4
1.49
-
adenosine 5'-phosphosulfate
pH 7.5, 37°C
Bos taurus
2.8.2.4
3.37
-
3'-AMP
pH 7.5, 37°C
Bos taurus
2.8.2.4
5
-
3'-AMP
pH 7.5, 37°C
Bos taurus
2.8.2.4
5
-
adenosine 5'-sulfate
pH 7.5, 37°C
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.4
3'-AMP
-
Bos taurus
2.8.2.4
adenosine 5'-phosphosulfate
-
Bos taurus
2.8.2.4
adenosine 5'-sulfate
-
Bos taurus
2.8.2.4
cetyltrimethylammonium bromide
-
Bos taurus
2.8.2.4
fatty acid
unsaturated fatty acid of chain length C11-C14
Bos taurus
2.8.2.4
myristate
inhibition is non-competitive with respect to the substrate estrone
Bos taurus
2.8.2.4
retinoic acid
-
Bos taurus
2.8.2.4
Sodium dodecyl sulfate
-
Bos taurus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.8.2.4
1.49
-
adenosine 5'-phosphosulfate
pH 7.5, 37°C
Bos taurus
2.8.2.4
3.37
-
3'-AMP
pH 7.5, 37°C
Bos taurus
2.8.2.4
5
-
3'-AMP
pH 7.5, 37°C
Bos taurus
2.8.2.4
5
-
adenosine 5'-sulfate
pH 7.5, 37°C
Bos taurus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.2.4
0.0027
-
estrone
pH 7.5, 37°C
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Bos taurus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Bos taurus
r
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.2.4
-
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
adrenal gland
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645868
Bos taurus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645868
Bos taurus
r