BRENDA - Enzyme Database show

Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues

Miki, Y.; Nakata, T.; Suzuki, T.; Darnel, A.D.; Moriya, T.; Kaneko, C.; Hidaka, K.; Shiotsu, Y.; Kusaka, H.; Sasano, H.; J. Clin. Endocrinol. Metab. 87, 5760-5768 (2002)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
estrone sulfate + H2O
Homo sapiens
STS converts the major circulating plasma estrogen estrone sulfate into the biologically active estrogene estrone, STS plays an important role in the in situ estrogen actions of various sex steroid-dependent tumors, peripheral STS plays a very important role in peripheral estrogen metabolism and actions in the human fetus
estrone + sulfate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.2
Homo sapiens
-
human
-
3.1.6.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.2
adrenal gland
-
Homo sapiens
-
2.8.2.2
epithelium
-
Homo sapiens
-
2.8.2.2
fetus
-
Homo sapiens
-
2.8.2.2
kidney
-
Homo sapiens
-
2.8.2.2
liver
-
Homo sapiens
-
2.8.2.2
placenta
-
Homo sapiens
-
2.8.2.2
skin
-
Homo sapiens
-
2.8.2.2
testis
-
Homo sapiens
-
2.8.2.2
uterus
-
Homo sapiens
-
3.1.6.2
adrenal gland
adult, relatively high STS activity
Homo sapiens
-
3.1.6.2
aorta
adult
Homo sapiens
-
3.1.6.2
liver
adult, relatively high STS activity
Homo sapiens
-
3.1.6.2
lung
adult
Homo sapiens
-
3.1.6.2
additional information
distribution of STS mRNA in human adult and fetal tissues
Homo sapiens
-
3.1.6.2
placenta
adult, highest STS activity
Homo sapiens
-
3.1.6.2
testis
adult
Homo sapiens
-
3.1.6.2
thyroid gland
adult
Homo sapiens
-
3.1.6.2
uterus
1-3.7% of the mRNA levels of placenta, adult
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.1.6.2
additional information
-
-
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
645797
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
STS converts the major circulating plasma estrogen estrone sulfate into the biologically active estrogene estrone, STS plays an important role in the in situ estrogen actions of various sex steroid-dependent tumors, peripheral STS plays a very important role in peripheral estrogen metabolism and actions in the human fetus
645797
Homo sapiens
estrone + sulfate
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
3.1.6.2
37
-
assay at
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
estrone sulfate + H2O
Homo sapiens
STS converts the major circulating plasma estrogen estrone sulfate into the biologically active estrogene estrone, STS plays an important role in the in situ estrogen actions of various sex steroid-dependent tumors, peripheral STS plays a very important role in peripheral estrogen metabolism and actions in the human fetus
estrone + sulfate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.2
adrenal gland
-
Homo sapiens
-
2.8.2.2
epithelium
-
Homo sapiens
-
2.8.2.2
fetus
-
Homo sapiens
-
2.8.2.2
kidney
-
Homo sapiens
-
2.8.2.2
liver
-
Homo sapiens
-
2.8.2.2
placenta
-
Homo sapiens
-
2.8.2.2
skin
-
Homo sapiens
-
2.8.2.2
testis
-
Homo sapiens
-
2.8.2.2
uterus
-
Homo sapiens
-
3.1.6.2
adrenal gland
adult, relatively high STS activity
Homo sapiens
-
3.1.6.2
aorta
adult
Homo sapiens
-
3.1.6.2
liver
adult, relatively high STS activity
Homo sapiens
-
3.1.6.2
lung
adult
Homo sapiens
-
3.1.6.2
additional information
distribution of STS mRNA in human adult and fetal tissues
Homo sapiens
-
3.1.6.2
placenta
adult, highest STS activity
Homo sapiens
-
3.1.6.2
testis
adult
Homo sapiens
-
3.1.6.2
thyroid gland
adult
Homo sapiens
-
3.1.6.2
uterus
1-3.7% of the mRNA levels of placenta, adult
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.1.6.2
additional information
-
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
645797
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
STS converts the major circulating plasma estrogen estrone sulfate into the biologically active estrogene estrone, STS plays an important role in the in situ estrogen actions of various sex steroid-dependent tumors, peripheral STS plays a very important role in peripheral estrogen metabolism and actions in the human fetus
645797
Homo sapiens
estrone + sulfate
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
3.1.6.2
37
-
assay at
Homo sapiens