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Literature summary extracted from

  • Faucher, F.; Lacoste, L.; Luu-The, V.
    Human type 1 estrogen sulfotransferase: catecholestrogen metabolism and potential involvement in cancer promotion (2002), Ann. N. Y. Acad. Sci., 963, 221-228.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.8.2.2 medicine hEST1 involved in the production of stable precursors for local steroid biosynthesis or in activation of promutagenic estrogen metabolites into carcinogens Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.2 3'-phosphoadenylylsulfate + dehydroepiandrosterone Homo sapiens catalyzes sulfonation of exogenous products like drugs and xenobiotics as well as endogenous compounds such as steroids and bile acids by transferring a sulfonate moiety from the cofactor 3'-phosphoadenosine-5'-phosphosulfate to a hydroxyl group of the substrate, this leads to detoxification or elimination because sulfation increases the hydrophilicity of chemical compounds and therefore their excretion, hEST1 also involved in the production of stable precursors for local steroid biosynthesis or in activation of promutagenic estrogen metabolites into carcinogens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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r

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Homo sapiens
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human
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylylsulfate + 2-hydroxy-catecholestrogen best substrate for this enzyme, also catalyzes the transformation of 4-hydroxy-estrogens and 16-hydroxy-estrogens, but with a lower affinity Homo sapiens adenosine 3',5'-bisphosphate + ?
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r
2.8.2.2 3'-phosphoadenylylsulfate + dehydroepiandrosterone
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Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r
2.8.2.2 3'-phosphoadenylylsulfate + dehydroepiandrosterone catalyzes sulfonation of exogenous products like drugs and xenobiotics as well as endogenous compounds such as steroids and bile acids by transferring a sulfonate moiety from the cofactor 3'-phosphoadenosine-5'-phosphosulfate to a hydroxyl group of the substrate, this leads to detoxification or elimination because sulfation increases the hydrophilicity of chemical compounds and therefore their excretion, hEST1 also involved in the production of stable precursors for local steroid biosynthesis or in activation of promutagenic estrogen metabolites into carcinogens Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 hEST1
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Homo sapiens
2.8.2.2 type 1 estrogen sulfotransferase
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Homo sapiens