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Literature summary extracted from

  • Singer, S.S.; Galaska, E.G.; Feeser, T.A.; Benak, R.L.; Ansel, A.Z.; Moloney, A.
    Enzymic sulfation of steroids. XIX. Cortisol sulfotransferase activity, glucocorticoid sulfotransferases, and tyrosine aminotransferase induction in chicken, gerbil, and hamster liver (1985), Can. J. Biochem. Cell Biol., 63, 23-32.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.18 3'-phosphoadenylylsulfate inhibition above 0.33 mM Gallus gallus
2.8.2.18 cortisol inhibition above 0.08 mM Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.18 0.009 0.016 cortisol pH 6.8 Gallus gallus
2.8.2.18 0.009 0.016 cortisol pH 6.8 Mesocricetus auratus
2.8.2.18 0.009 0.016 cortisol pH 6.8 Meriones sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.18 98300
-
 gel filtration Meriones sp.
2.8.2.18 105000
-
 gel filtration Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Gallus gallus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Mesocricetus auratus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Meriones sp.
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.18 Gallus gallus
-
 cornish rock chicken, two isozymes
-
2.8.2.18 Meriones sp.
-
 Tan gerbil, four isozymes
-
2.8.2.18 Mesocricetus auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.18 liver
-
 Gallus gallus
-
2.8.2.18 liver
-
 Mesocricetus auratus
-
2.8.2.18 liver
-
 Meriones sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Gallus gallus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Mesocricetus auratus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Meriones sp. adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol requires 0.5 mM cortisol for maximal activity Mesocricetus auratus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol requires 0.5 mM cortisol for maximal activity Meriones sp. adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol requires 0.04 mM cortisol for maximal activity Gallus gallus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.18 5.9
-
-
 Gallus gallus
2.8.2.18 6.3
-
-
 Meriones sp.
2.8.2.18 7.1
-
-
 Mesocricetus auratus