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Literature summary extracted from

  • Singer, S.S.
    Glucocorticoid sulphotransferases in rats and other animal species (1984), Biochem. Soc. Trans., 12, 35-39.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.18 Antibodies to sulfotransferase III sulfotransferase I Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.18 0.007
-
 cortisol pH 6.8, sulfotransferase I and III Rattus norvegicus
2.8.2.18 0.007
-
 3'-phosphoadenylylsulfate pH 6.8, sulfotransferase III Rattus norvegicus
2.8.2.18 0.007 0.02 cortisol
-
 Gallus gallus
2.8.2.18 0.007 0.02 cortisol
-
 Bos taurus
2.8.2.18 0.011
-
 3'-phosphoadenylylsulfate pH 6.8, sulfotransferase I Rattus norvegicus
2.8.2.18 0.15 0.188 3'-phosphoadenylylsulfate
-
 Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.18 cytosol
-
 Gallus gallus 5829
-
2.8.2.18 cytosol
-
 Cavia porcellus 5829
-
2.8.2.18 cytosol
-
 Rattus norvegicus 5829
-
2.8.2.18 cytosol
-
 Bos taurus 5829
-
2.8.2.18 cytosol
-
 Mesocricetus auratus 5829
-
2.8.2.18 cytosol
-
 Meriones sp. 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.18 28000
-
 6 * 28000, sulfotransferase I, SDS-PAGE Rattus norvegicus
2.8.2.18 30000
-
 2 * 30000, sulfotransferase III, SDS-PAGE Rattus norvegicus
2.8.2.18 160000
-
 sulfotransferase I Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Gallus gallus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Cavia porcellus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Bos taurus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Mesocricetus auratus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Meriones sp.
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 additional information Rattus norvegicus involved in control of corticosteroid metabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.18 Bos taurus
-
-
-
2.8.2.18 Cavia porcellus
-
-
-
2.8.2.18 Gallus gallus
-
-
-
2.8.2.18 Meriones sp.
-
-
-
2.8.2.18 Mesocricetus auratus
-
-
-
2.8.2.18 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.18 sulfotransferase I Rattus norvegicus
2.8.2.18 the use of frozen liver or cytosol stored on ice for more than 1-2 h reduces the yield of sulfotransferase I greatly Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.18 liver
-
 Gallus gallus
-
2.8.2.18 liver
-
 Cavia porcellus
-
2.8.2.18 liver
-
 Rattus norvegicus
-
2.8.2.18 liver
-
 Bos taurus
-
2.8.2.18 liver
-
 Mesocricetus auratus
-
2.8.2.18 liver
-
 Meriones sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Gallus gallus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Cavia porcellus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Bos taurus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Mesocricetus auratus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Meriones sp. adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 additional information involved in control of corticosteroid metabolism Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.18 dimer 2 * 30000, sulfotransferase III, SDS-PAGE Rattus norvegicus
2.8.2.18 hexamer 6 * 28000, sulfotransferase I, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.18 additional information
-
 pI: 6.5 Gallus gallus
2.8.2.18 additional information
-
 pI: 6.5 Rattus norvegicus
2.8.2.18 additional information
-
 pI: 6.5 Bos taurus
2.8.2.18 additional information
-
 pI: 6.5 Mesocricetus auratus
2.8.2.18 additional information
-
 pI: 6.5 Meriones sp.
2.8.2.18 6
-
 cortisol as substrate Rattus norvegicus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.8.2.18 Rattus norvegicus
-
-
 6.5