BRENDA - Enzyme Database show

Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta

Nakamura, Y.; Miki, Y.; Suzuki, T.; Nakata, T.; Darnel, A.D.; Moriya, T.; Tazawa, C.; Saito, H.; Ishibashi, T.; Takahashi, S.; Yamada, S.; Sasano, H.; Am. J. Pathol. 163, 1329-1339 (2003)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.8.2.4
medicine
diagnosis of atherosclerotic changes, enzymatic distribution and involvement in the development and pathogenesis of atherosclerosis is different between males and females
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
2.8.2.4
-
Homo sapiens
2.8.2.15
cDNA for isozymes STS and EST cloned
Homo sapiens
3.1.6.2
-
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
interleukin-1beta
marked inhibition of mRNA expression and STS activity
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Homo sapiens
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Homo sapiens
r
3.1.6.2
estrone sulfate + H2O
Homo sapiens
STS plays an important role in the in situ estrogen actions of estrogen-dependent human tissues and various sex steroid-dependent tumors, STS may be associated with the degree of atherosclerotic changes in the female aorta, transformation of the biologically inactive form of plasma estrogen in its active form
estrone + sulfate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.4
Homo sapiens
-
human
-
2.8.2.15
Homo sapiens
-
human
-
3.1.6.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
abdomen
-
Homo sapiens
-
2.8.2.4
aorta
female aortic smooth muscle cell line CRL-1999 cell
Homo sapiens
-
2.8.2.4
T/G HA-VSMC cell
-
Homo sapiens
-
2.8.2.15
aorta
aortic smooth muscle cell line CRL-1999
Homo sapiens
-
2.8.2.15
muscle
aortic smooth muscle cell line CRL-1999
Homo sapiens
-
3.1.6.2
aorta
abdominal, STS expression levels are higher in the vascular smooth muscle cells obtained from female aortas with mild atherosclerotic changes than in those with severe atherosclerotic changes in male aortas regardless of atherosclerotic changes
Homo sapiens
-
3.1.6.2
additional information
not in endothelial cells or inflammatory cells including macrophages
Homo sapiens
-
3.1.6.2
T/G HA-VSMC cell
human female vascular smooth muscle cell line
Homo sapiens
-
3.1.6.2
vascular smooth muscle
STS expression levels are higher in the vascular smooth muscle cells obtained from female aortas with mild atherosclerotic changes than in those with severe atherosclerotic changes in male aortas regardless of atherosclerotic changes
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.1.6.2
additional information
-
STS activities in male or female aortas with different degrees of atherosclerotic changes
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645740
Homo sapiens
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645740
Homo sapiens
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645740
Homo sapiens
r
3.1.6.2
estrone sulfate + H2O
-
645740
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
STS plays an important role in the in situ estrogen actions of estrogen-dependent human tissues and various sex steroid-dependent tumors, STS may be associated with the degree of atherosclerotic changes in the female aorta, transformation of the biologically inactive form of plasma estrogen in its active form
645740
Homo sapiens
estrone + sulfate
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
3.1.6.2
37
-
assay at
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
2.8.2.4
medicine
diagnosis of atherosclerotic changes, enzymatic distribution and involvement in the development and pathogenesis of atherosclerosis is different between males and females
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.2.4
-
Homo sapiens
2.8.2.15
cDNA for isozymes STS and EST cloned
Homo sapiens
3.1.6.2
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
interleukin-1beta
marked inhibition of mRNA expression and STS activity
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Homo sapiens
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Homo sapiens
r
3.1.6.2
estrone sulfate + H2O
Homo sapiens
STS plays an important role in the in situ estrogen actions of estrogen-dependent human tissues and various sex steroid-dependent tumors, STS may be associated with the degree of atherosclerotic changes in the female aorta, transformation of the biologically inactive form of plasma estrogen in its active form
estrone + sulfate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
abdomen
-
Homo sapiens
-
2.8.2.4
aorta
female aortic smooth muscle cell line CRL-1999 cell
Homo sapiens
-
2.8.2.4
T/G HA-VSMC cell
-
Homo sapiens
-
2.8.2.15
aorta
aortic smooth muscle cell line CRL-1999
Homo sapiens
-
2.8.2.15
muscle
aortic smooth muscle cell line CRL-1999
Homo sapiens
-
3.1.6.2
aorta
abdominal, STS expression levels are higher in the vascular smooth muscle cells obtained from female aortas with mild atherosclerotic changes than in those with severe atherosclerotic changes in male aortas regardless of atherosclerotic changes
Homo sapiens
-
3.1.6.2
additional information
not in endothelial cells or inflammatory cells including macrophages
Homo sapiens
-
3.1.6.2
T/G HA-VSMC cell
human female vascular smooth muscle cell line
Homo sapiens
-
3.1.6.2
vascular smooth muscle
STS expression levels are higher in the vascular smooth muscle cells obtained from female aortas with mild atherosclerotic changes than in those with severe atherosclerotic changes in male aortas regardless of atherosclerotic changes
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.1.6.2
additional information
-
STS activities in male or female aortas with different degrees of atherosclerotic changes
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645740
Homo sapiens
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645740
Homo sapiens
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645740
Homo sapiens
r
3.1.6.2
estrone sulfate + H2O
-
645740
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
STS plays an important role in the in situ estrogen actions of estrogen-dependent human tissues and various sex steroid-dependent tumors, STS may be associated with the degree of atherosclerotic changes in the female aorta, transformation of the biologically inactive form of plasma estrogen in its active form
645740
Homo sapiens
estrone + sulfate
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
3.1.6.2
37
-
assay at
Homo sapiens