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Literature summary extracted from

  • Nakamura, Y.; Miki, Y.; Suzuki, T.; Nakata, T.; Darnel, A.D.; Moriya, T.; Tazawa, C.; Saito, H.; Ishibashi, T.; Takahashi, S.; Yamada, S.; Sasano, H.
    Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta (2003), Am. J. Pathol., 163, 1329-1339.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.8.2.4 medicine diagnosis of atherosclerotic changes, enzymatic distribution and involvement in the development and pathogenesis of atherosclerosis is different between males and females Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.4
-
 Homo sapiens
2.8.2.15 cDNA for isozymes STS and EST cloned Homo sapiens
3.1.6.2
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 interleukin-1beta marked inhibition of mRNA expression and STS activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone Homo sapiens
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r
3.1.6.2 estrone sulfate + H2O Homo sapiens STS plays an important role in the in situ estrogen actions of estrogen-dependent human tissues and various sex steroid-dependent tumors, STS may be associated with the degree of atherosclerotic changes in the female aorta, transformation of the biologically inactive form of plasma estrogen in its active form estrone + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Homo sapiens
-
 human
-
2.8.2.15 Homo sapiens
-
 human
-
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 abdomen
-
 Homo sapiens
-
2.8.2.4 aorta female aortic smooth muscle cell line CRL-1999 cell Homo sapiens
-
2.8.2.4 T/G HA-VSMC cell
-
 Homo sapiens
-
2.8.2.15 aorta aortic smooth muscle cell line CRL-1999 Homo sapiens
-
2.8.2.15 muscle aortic smooth muscle cell line CRL-1999 Homo sapiens
-
3.1.6.2 aorta abdominal, STS expression levels are higher in the vascular smooth muscle cells obtained from female aortas with mild atherosclerotic changes than in those with severe atherosclerotic changes in male aortas regardless of atherosclerotic changes Homo sapiens
-
3.1.6.2 additional information not in endothelial cells or inflammatory cells including macrophages Homo sapiens
-
3.1.6.2 T/G HA-VSMC cell human female vascular smooth muscle cell line Homo sapiens
-
3.1.6.2 vascular smooth muscle STS expression levels are higher in the vascular smooth muscle cells obtained from female aortas with mild atherosclerotic changes than in those with severe atherosclerotic changes in male aortas regardless of atherosclerotic changes Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.6.2 additional information
-
 STS activities in male or female aortas with different degrees of atherosclerotic changes Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r
3.1.6.2 estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
3.1.6.2 estrone sulfate + H2O STS plays an important role in the in situ estrogen actions of estrogen-dependent human tissues and various sex steroid-dependent tumors, STS may be associated with the degree of atherosclerotic changes in the female aorta, transformation of the biologically inactive form of plasma estrogen in its active form Homo sapiens estrone + sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.4 EST
-
 Homo sapiens
2.8.2.15 steroid sulfatase
-
 Homo sapiens
3.1.6.2 STS
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.6.2 37
-
 assay at Homo sapiens