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Literature summary extracted from

  • Chen, L.J.; Segel, I.H.
    Purification and characterization of bile salt sulfotransferase from human liver (1985), Arch. Biochem. Biophys., 241, 371-379.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.14 3-ketolithocholate
-
 Homo sapiens
2.8.2.14 adenosine-3',5'-diphosphate
-
 Homo sapiens
2.8.2.14 glycolithocholate
-
 Homo sapiens
2.8.2.14 p-chloromercuribenzoate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.14 0.0007
-
 3'-phosphoadenylylsulfate pH 6.5, 37°C Homo sapiens
2.8.2.14 0.002
-
 glycolithocholate pH 6.5, 37°C Homo sapiens
2.8.2.14 0.0024
-
 5-cholenic acid-3beta-ol pH 6.5, 37°C Homo sapiens
2.8.2.14 0.0025
-
 lithocholate pH 6.5, 37°C Homo sapiens
2.8.2.14 0.025
-
 3alpha-7alpha-chenodeoxycholic acid pH 6.5, 37°C Homo sapiens
2.8.2.14 0.071
-
 3alpha,7alpha,12alpha-cholic acid pH 6.5, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.14 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.14 65000
-
 gel filtration Homo sapiens
2.8.2.14 67000
-
 gel filtration Homo sapiens
2.8.2.14 68000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.14 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.14
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.14 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.14 0.018
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.14 3'-phosphoadenylyl sulfate + 3alpha-7alpha-chenodeoxycholic acid
-
 Homo sapiens ?
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + 3alpha,7alpha,12alpha-cholic acid
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3alpha,7alpha,12alpha-cholic acid sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + 5-cholenic acid-3beta-ol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 5-cholenic acid-3-beta-ol sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + cholic acid
-
 Homo sapiens adenosine 3',5'-bisphosphate + cholic acid sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + glycolithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + lithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?
2.8.2.14 additional information purified enzyme displays no activity toward estrone, testosterone, or phenol Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.14 BSS
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.14 6.5
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.8.2.14 5.5 10.5 50% maximum activity at pH 5.8 and pH 7.5 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.14 0.0002
-
 adenosine-3',5'-diphosphate pH 6.5, 37°C Homo sapiens
2.8.2.14 0.0006
-
 3-ketolithocholate pH 6.5, 37°C Homo sapiens
2.8.2.14 0.0022
-
 glycolithocholate pH 6.5, 37°C Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.8.2.14 Homo sapiens isoelectric focusing electrophoresis
-
 5.2