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Literature summary extracted from

  • Loeoef, L.; Wengle, B.
    Enzymatic sulphation of bile salts in human liver (1978), Biochim. Biophys. Acta, 530, 451-460.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.8.2.14 medicine assay for bile salt sulfotransferase renders it possible to estimate this enzyme in percutaneous liver biopsy specimens. By application of this technique it will be possible to study this enzyme in patients with various liver diseases Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.14 0.002
-
 lithocholate pH 6.8, 37°C Homo sapiens
2.8.2.14 0.0033
-
 glycolithocholate pH 6.8, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.14 cytosol
-
 Homo sapiens 5829
-
2.8.2.14 additional information no activity in microsomes Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.14 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.14 liver
-
 Homo sapiens
-
2.8.2.14 additional information no activity in kidney Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.14 3'-phosphoadenylyl-sulfate + glycolithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + lithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.14 7.5 9
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.8.2.14 5.5 10.5 55% of activity maximum at pH 5.5 and pH 10.5 Homo sapiens