Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tsoi, C.; Morgenstern, R.; Swedmark, S.
    Canine sulfotransferase SULT1A1: molecular cloning, expression, and characterization (2002), Arch. Biochem. Biophys., 401, 125-133.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli Canis lupus familiaris
2.8.2.1 DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli BL21(DE3) as His-tagged protein Canis lupus familiaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 1-naphthol SULT1A1, substrate inhibition at 0.0005 mM Canis lupus familiaris
2.8.2.1 4-nitrophenol SULT1A1, substrate inhibition at 0.001 mM Canis lupus familiaris

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.000069
-
 4-nitrophenol SULT1A1, pH 7.3-7.4 Canis lupus familiaris
2.8.2.1 0.00015
-
 4-nitrophenol SULT1A1, pH 7.0 Canis lupus familiaris
2.8.2.1 0.014
-
 beta-estradiol SULT1A1, pH 7.3-7.4 Canis lupus familiaris
2.8.2.1 0.175
-
 dopamine SULT1A1, pH 7.0 Canis lupus familiaris
2.8.2.1 0.18
-
 dopamine SULT1A1, pH 7.3-7.4 Canis lupus familiaris
2.8.2.1 0.55
-
 minoxidil SULT1A1, pH 7.3-7.4 Canis lupus familiaris

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol SULT1A1 Canis lupus familiaris 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Canis lupus familiaris Q29476 SULT1A1, 100% identical in amino acid sequence with GenBank accession number D29807
-
2.8.2.1 Canis lupus familiaris Q29476 P-PST, 100% identical in amino acid sequence with GenBank accession number AY069922
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.1 recombinant His-tagged enzyme from Escherichia coli Canis lupus familiaris

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 colon SULT1A1 Canis lupus familiaris
-
2.8.2.1 duodenum
-
 Canis lupus familiaris
-
2.8.2.1 duodenum SULT1A1 Canis lupus familiaris
-
2.8.2.1 duodenum higher content in male than in female dogs Canis lupus familiaris
-
2.8.2.1 ileum
-
 Canis lupus familiaris
-
2.8.2.1 ileum SULT1A1 Canis lupus familiaris
-
2.8.2.1 ileum higher content in male than in female dogs Canis lupus familiaris
-
2.8.2.1 jejunum
-
 Canis lupus familiaris
-
2.8.2.1 jejunum SULT1A1 Canis lupus familiaris
-
2.8.2.1 jejunum higher content in male than in female dogs Canis lupus familiaris
-
2.8.2.1 kidney SULT1A1, higher content in male than in female dogs Canis lupus familiaris
-
2.8.2.1 liver SULT1A1 Canis lupus familiaris
-
2.8.2.1 lung SULT1A1 Canis lupus familiaris
-
2.8.2.1 rectum SULT1A1 Canis lupus familiaris
-
2.8.2.1 skin SULT1A1 Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
 Canis lupus familiaris adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 2-naphthol SULT1A1 Canis lupus familiaris adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol
-
 Canis lupus familiaris adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol SULT1A1 Canis lupus familiaris adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + beta-estradiol SULT1A1 Canis lupus familiaris adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine SULT1A1 Canis lupus familiaris adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + minoxidil SULT1A1 Canis lupus familiaris adenosine 3',5'-bisphosphate + minoxidil sulfate
-
 ?
2.8.2.1 additional information
-
 Canis lupus familiaris ?
-
 ?
2.8.2.1 additional information no activity with dehydroepiandrosterone Canis lupus familiaris ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT
-
 Canis lupus familiaris

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 7
-
 assay at Canis lupus familiaris
2.8.2.1 7.4
-
 assay at Canis lupus familiaris