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Literature summary extracted from

  • Li, X.; Clemens, D.L.; Cole, J.R.; Anderson, R.J.
    Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate (2001), J. Endocrinol., 171, 525-532.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 expression of SULT1A1 allozymes 1 and 2 in COS-1 cells, amino acid sequence determination Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.00051
-
 3,3'-diiodo-L-thyronine SULT1A1 allozyme 2, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.00063
-
 3,3'-diiodo-L-thyronine SULT1A1 allozyme 1, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.036
-
 3,3',5'-triiodo-L-thyronine SULT1A1 allozyme 1, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.05
-
 3,3',5'-triiodo-L-thyronine SULT1A1 allozyme 2, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.084
-
 3,3',5-triiodo-L-thyronine SULT1A1 allozyme 1, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.101
-
 L-thyroxine SULT1A1 allozyme 1, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.126
-
 3,3',5-triiodo-L-thyronine SULT1A1 allozyme 2, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.208
-
 L-thyroxine SULT1A1 allozyme 2, pH 7.0, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens P50225 SULT1A1 allozymes 1 and 2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 liver SULT1A1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3',5'-triiodo-L-thyronine SULT1A1 allozymes 1 and 2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine SULT1A1 allozymes 1 and 2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine SULT1A1 allozymes 1 and 2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3'-diiodo-L-thyronine low activity Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3'-diiodo-L-thyronine SULT1A1 allozymes 1 and 2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,5-diiodo-L-thyronine no activity with Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + L-thyroxine SULT1A1 allozymes 1 and 2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
 assay at Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.8.2.1 44.5
-
 50% inactivation, SULT1A1 allozymes 2 Homo sapiens
2.8.2.1 46.9
-
 50% inactivation, SULT1A1 allozymes 1 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 7
-
 assay at Homo sapiens