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Literature summary extracted from

  • Sakakibara, Y.; Takami, Y.; Zwieb, C.; Nakayama, T.; Suiko, M.; Nakamima, H.; Liu, M.C.
    Purification, characterization, and molecular cloning of a novel rat liver dopa/tyrosine sulfotransferase (1995), J. Biol. Chem., 270, 30470-30478.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 DNA and amino acid sequence determination and analysis, transient expression of Dopa/tyrosine sulfotransferase in COS-7 cells and Escherichia coli XL1-Blue Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 3,3',5-triiodo-L-thyronine substrate inhibition at 0.25 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.24
-
 dopamine pH 9.3, 37°C Rattus norvegicus
2.8.2.1 0.76
-
 L-3,4-dihydroxyphenylalanine pH 9.3, 37°C Rattus norvegicus
2.8.2.1 3.44
-
 D-3,4-dihydroxyphenylalanine pH 9.3, 37°C Rattus norvegicus
2.8.2.1 30.9
-
 4-nitrophenol pH 9.3, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.1 34000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Rattus norvegicus P52847
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.1 764fold, to homogeneity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.1 0.0022
-
 purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3',5'-triiodo-L-thyronine low activity Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3,5-diiodo-L-thyronine low activity Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + DL-tyrosine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + L-tyrosine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + L-tyrosyl O4-sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 9.3
-
-
 Rattus norvegicus