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Literature summary extracted from
- Purification and kinetic characterization of a phenol-sulfating form of phenol sulfotransferase from human brain (1986), Arch. Biochem. Biophys., 249, 464-471.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.2.1 | 2,6-Dichloro-4-nitrophenol | PI-PST and PII-PST | Homo sapiens |  |
| 2.8.2.1 | 3'-phosphoadenylylsulfate | substrate inhibition | Homo sapiens | |
| 2.8.2.1 | NaCl | PI-PST: 50% inhibition at 100 mM, PII-PST: 20% inhibition at 0.3 M | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.2.1 | 0.00035 | - |
3'-phosphoadenylylsulfate | pH 8.5 | Homo sapiens | |
| 2.8.2.1 | 0.833 | - |
tyrosylglycine | pH 8.5 | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.8.2.1 | Homo sapiens | - |
2 forms of P-PST: PI-PST and PII-PST | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.8.2.1 | 389fold | Homo sapiens |
| 2.8.2.1 | phenol-sulfating form, P-PST | Homo sapiens |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate | isozyme P-PST: sequential ordered bisubstrate reaction mechanism | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.8.2.1 | brain | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | 0.0024 | - |
purified P1-PST | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
r | |
| 2.8.2.1 | 3'-phosphoadenylylsulfate + tyrosylglycine | - |
Homo sapiens | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | 8.5 | - |
- |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | additional information | - |
- |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.2.1 | 0.00035 | - |
3'-phosphoadenylylsulfate | P-PST, pH 8.5 | Homo sapiens | |
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