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Literature summary extracted from

  • Ugulava, N.B.; Sacanell, C.J.; Jarrett, J.T.
    Spectroscopic changes during a single turnover of biotin synthase: Destruction of a [2Fe-2S] cluster accompanies sulfur insertion (2001), Biochemistry, 40, 8352-8358.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.1.6 dithiothreitol
-
 Escherichia coli
2.8.1.6 flavodoxin reductase omission results in a 100fold decrease in activity Escherichia coli
2.8.1.6 S-adenosyl-L-methionine required Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.1.6 FeCl3
-
 Escherichia coli
2.8.1.6 Iron 1 [2Fe-2S] and 1 [4Fe-4S] cluster per monomer are essential for optimal activity Escherichia coli
2.8.1.6 Na2S
-
 Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.1.6 38400
-
 2 * 38400 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.6 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.1.6
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur insertion of a sulfur atom between the saturated C6 and C9 carbons of dethiobiotin Escherichia coli biotin
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.1.6 dimer 2 * 38400 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.1.6 flavodoxin required Escherichia coli
2.8.1.6 NADPH omission results in a 100fold decrease in activity Escherichia coli