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Literature summary extracted from

  • Bui, B.T.S.; Florentin, D.; Fournier, F.; Ploux, O.; Mejean, A.; Marquet, A.
    Biotin synthase mechanism: on the origin of sulfur (1998), FEBS Lett., 440, 226-230.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.1.6 FeCl3
-
 Escherichia coli
2.8.1.6 FeCl3 enhances activity 3-4fold at 0.1 mM Lysinibacillus sphaericus
2.8.1.6 Iron the enzyme contains an iron-sulfur cluster Escherichia coli
2.8.1.6 Iron the enzyme contains an iron-sulfur cluster Lysinibacillus sphaericus
2.8.1.6 Na2S
-
 Escherichia coli
2.8.1.6 Na2S enhances activity 3-4fold at 1 mM Lysinibacillus sphaericus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur Escherichia coli hypothesis: sulfur of biotin is derived from the [Fe-S] center of the enzyme biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur Lysinibacillus sphaericus hypothesis: sulfur of biotin is derived from the [Fe-S] center of the enzyme biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur Escherichia coli catalyzes the last step of the biosynthesis of biotin biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur Lysinibacillus sphaericus catalyzes the last step of the biosynthesis of biotin biotin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.6 Escherichia coli
-
-
-
2.8.1.6 Lysinibacillus sphaericus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.8.1.6 dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin mechanism Escherichia coli
a
2.8.1.6 dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin mechanism Lysinibacillus sphaericus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur
-
 Escherichia coli biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur
-
 Lysinibacillus sphaericus biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur hypothesis: sulfur of biotin is derived from the [Fe-S] center of the enzyme Escherichia coli biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur hypothesis: sulfur of biotin is derived from the [Fe-S] center of the enzyme Lysinibacillus sphaericus biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur catalyzes the last step of the biosynthesis of biotin Escherichia coli biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur catalyzes the last step of the biosynthesis of biotin Lysinibacillus sphaericus biotin
-
 ?