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Literature summary extracted from

  • Birch, O.M.; Fuhrmann, M.; Shaw, N.M.
    Biotin synthase from Escherichia coli, an investigation of the low molecular weight and protein components required for activity in vitro (1995), J. Biol. Chem., 270, 19158-19165.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.1.6 amino acid one of the amino acids: Asn, Asp, Gln or Ser Escherichia coli
2.8.1.6 L-cysteine required as sulfur donor Escherichia coli
2.8.1.6 Pyridine nucleotide required, NADPH being most effective Escherichia coli
2.8.1.6 S-adenosyl-L-methionine required Escherichia coli
2.8.1.6 thiamine diphosphate-dependent protein required Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.1.6
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.1.6 Fe2+ required Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.6 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur
-
 Escherichia coli biotin
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.1.6 Ferredoxin required Escherichia coli
2.8.1.6 flavodoxin required Escherichia coli
2.8.1.6 thiamine diphosphate required Escherichia coli