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Literature summary extracted from

  • Alphey, M.S.; Williams, R.A.; Mottram, J.C.; Coombs, G.H.; Hunter, W.N.
    The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site (2003), J. Biol. Chem., 278, 48219-48227.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.8.1.2 hanging drop vapor diffusion method Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.1.2 N-alpha-4-tosyl-L-lysine chloromethyl ketone interferes with Ser-255, 50% inhibition at 0.044 mM Leishmania major
2.8.1.2 phenylmethanesulfonyl chloride 50% inhibition at 0.7 mM Leishmania major

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.1.2 3-mercaptopyruvate + cyanide Leishmania major
-
pyruvate + thiocyanate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.2 Leishmania major
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.2 3-mercaptopyruvate + cyanide
-
Leishmania major pyruvate + thiocyanate
-
?