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Literature summary extracted from
- 3-Mercaptopyruvate sulfurtransferase (1981), Methods Enzymol., 77, 291-297.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.1.2 | pyruvate | product inhibition, competitive with 3-mercaptopyruvate and 2-mercaptoethanol | Bos taurus |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.1.2 | Cu2+ | enzyme contains 0.5 mol of copper | Bos taurus | |
| 2.8.1.2 | Zn2+ | enzyme contains 0.1 mol of zinc | Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.8.1.2 | 33000 | - |
gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.1.2 | 3-mercaptopyruvate + cyanide | Bos taurus | - |
pyruvate + thiocyanate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.8.1.2 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.8.1.2 | - |
Bos taurus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 2.8.1.2 | 3-mercaptopyruvate + reduced thioredoxin = pyruvate + hydrogen sulfide + oxidized thioredoxin | rapid equilibrium-ordered mechanism with 3-mercaptopyruvate as the first substrate | Bos taurus | |
| 2.8.1.2 | 3-mercaptopyruvate + reduced thioredoxin = pyruvate + hydrogen sulfide + oxidized thioredoxin | sequential formal mechanism | Bos taurus | |
| 2.8.1.2 | 3-mercaptopyruvate + reduced thioredoxin = pyruvate + hydrogen sulfide + oxidized thioredoxin | when 2-mercaptoethanol is the sulfur acceptor addition of the substrate is random | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.8.1.2 | kidney | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.8.1.2 | 1240 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.1.2 | 3-mercaptopyruvate + cyanide | - |
Bos taurus | pyruvate + thiocyanate | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 2.8.1.2 | 30 | - |
assay at | Bos taurus |
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Release 2023.1 (January 2023)
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