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Literature summary extracted from

  • Guimaraes, M.J.; Peterson, D.; Vicari, A.; Cocks, B.G.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Ferrick, D.A.; Kastelein, R.A.; Bazan, J.F.; Zlotnik, A.
    Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: Is there an autoregulatory mechanism in selenocysteine metabolism? (1996), Proc. Natl. Acad. Sci. USA, 93, 15086-15091.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.9.3 DNA sequence determination and analysis Homo sapiens
2.7.9.3 DNA sequence determination and analysis, chromosomal mapping, expression in COS-7 cells as FLAG tagged enzyme Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.9.3 ATP + selenide + H2O Homo sapiens required for synthesis of selenocysteine and seleno-tRNAs AMP + selenophosphate + phosphate
-
 ?
2.7.9.3 ATP + selenide + H2O Mus musculus required for synthesis of selenocysteine and seleno-tRNAs AMP + selenophosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.9.3 Haemophilus influenzae
-
 DNA sequence comparison
-
2.7.9.3 Homo sapiens Q99611 gene selD
-
2.7.9.3 Methanocaldococcus jannaschii
-
 DNA sequence comparison
-
2.7.9.3 Mus musculus P97364 gene selD
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.9.3 recombinant from COS-7 cells as FLAG tagged enzyme Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.9.3 FDCP-Mix cl.A4 cell low expression level Mus musculus
-
2.7.9.3 kidney low expression level Mus musculus
-
2.7.9.3 liver adult and fetal Mus musculus
-
2.7.9.3 testis
-
 Mus musculus
-
2.7.9.3 yolk sac very low expression level Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.9.3 ATP + selenide + H2O
-
 Haemophilus influenzae AMP + selenophosphate + phosphate
-
 ?
2.7.9.3 ATP + selenide + H2O
-
 Homo sapiens AMP + selenophosphate + phosphate
-
 ?
2.7.9.3 ATP + selenide + H2O
-
 Mus musculus AMP + selenophosphate + phosphate
-
 ?
2.7.9.3 ATP + selenide + H2O required for synthesis of selenocysteine and seleno-tRNAs Homo sapiens AMP + selenophosphate + phosphate
-
 ?
2.7.9.3 ATP + selenide + H2O required for synthesis of selenocysteine and seleno-tRNAs Mus musculus AMP + selenophosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.9.3 Sps2
-
 Homo sapiens
2.7.9.3 Sps2
-
 Mus musculus