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Literature summary extracted from

  • Gehring, A.M.; Lambalot, R.H.; Vogel, K.W.; Drueckhammer, D.G.; Walsh, C.T.
    Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase (1997), Chem. Biol., 4, 17-24.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.7 apo-acyl-carrier protein
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.7 0.002
-
 apo-acyl-carrier protein pH 7.0, 37°C, Escherichia coli acyl carrier protein Escherichia coli
2.7.8.7 0.005
-
 apo-[Streptomyces sp. granaticin-acyl-carrier protein] pH 7.0, 37°C, Escherichia coli acyl carrier protein Escherichia coli
2.7.8.7 0.012
-
 apo-[Streptomyces sp. frenolicin-acyl-carrier protein] pH 7.0, 37°C, Escherichia coli acyl carrier protein Escherichia coli
2.7.8.7 0.022
-
 apo-[Streptomyces sp. tetracenomycin-acyl-carrier protein(His6)] pH 7.0, 37°C, Escherichia coli acyl carrier protein Escherichia coli
2.7.8.7 0.039
-
 apo-[Streptomyces sp. oxytetracycline-acyl-carrier protein] pH 7.0, 37°C, Escherichia coli acyl carrier protein Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.7 CoA + apo-[acyl-carrier protein] Escherichia coli
-
 adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.7 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.7 acetonyldethio-CoA + apo-[acyl-carrier protein]
-
 Escherichia coli ? + holo-[acyl-carrier protein]
-
 r
2.7.8.7 CoA + apo-[acyl-carrier protein]
-
 Escherichia coli adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
2.7.8.7 CoA + apo-[acyl-carrier protein] Streptomycess sp. acyl carrier proteins and coenzyme A analogs also serves as substrates for holo-ACP synthase in vitro Escherichia coli adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
2.7.8.7 CoA + apo-[Streptomyces sp. frenolicin-acyl-carrier protein]
-
 Escherichia coli adenosine 3',5'-bisphosphate + holo-[Streptomyces sp. frenolicin-acyl-carrier protein]
-
 r
2.7.8.7 CoA + apo-[Streptomyces sp. granaticin-acyl-carrier protein]
-
 Escherichia coli adenosine 3',5'-bisphosphate + holo-[Streptomyces sp. granaticin-acyl-carrier protein]
-
 r
2.7.8.7 CoA + apo-[Streptomyces sp. oxytetracycline-acyl-carrier protein]
-
 Escherichia coli adenosine 3',5'-bisphosphate + holo-[Streptomyces sp. oxytetracycline-acyl-carrier protein]
-
 r
2.7.8.7 CoA + apo-[Streptomyces sp. tetracenomycin-acyl-carrier protein(His6)]
-
 Escherichia coli adenosine 3',5'-bisphosphate + holo-[Streptomyces sp. tetracenomycin-acyl-carrier protein(His6)]
-
 r
2.7.8.7 desulfo-CoA + apo-[acyl-carrier protein]
-
 Escherichia coli ? + holo-[acyl-carrier protein]
-
 r
2.7.8.7 desulfoCoA + apo-[Streptomyces sp. oxytetracycline-acyl-carrier protein]
-
 Escherichia coli ? + holo-[Streptomyces sp. oxytetracycline-acyl-carrier protein]
-
 r
2.7.8.7 homocysteamine-CoA + apo-[acyl-carrier protein]
-
 Escherichia coli ? + holo-[acyl-carrier protein]
-
 r

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.8.7 0.09
-
 apo-[Streptomyces sp. tetracenomycin-acyl-carrier protein(His6)] pH 7.0, 37°C, E. coli ACP Escherichia coli
2.7.8.7 0.167
-
 apo-[Streptomyces sp. oxytetracycline-acyl-carrier protein] pH 7.0, 37°C, E. coli ACP Escherichia coli
2.7.8.7 0.317
-
 apo-[Streptomyces sp. frenolicin-acyl-carrier protein] pH 7.0, 37°C, E. coli ACP Escherichia coli
2.7.8.7 0.5
-
 apo-[Streptomyces sp. granaticin-acyl-carrier protein] pH 7.0, 37°C, E. coli ACP Escherichia coli
2.7.8.7 1.33 1.67 apo-acyl-carrier protein pH 7.0, 37°C, E. coli ACP Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.8.7 0.0006
-
 apo-[Streptomyces sp. granaticin-acyl-carrier protein] pH 7.0, 37°C, E. coli ACP Escherichia coli
2.7.8.7 0.002
-
 apo-acyl-carrier protein pH 7.0, 37°C, E. coli ACP Escherichia coli
2.7.8.7 0.054
-
 apo-[Streptomyces sp. frenolicin-acyl-carrier protein] pH 7.0, 37°C, E. coli ACP Escherichia coli