Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kennedy, E.P.
    Phosphorylcholine-ceramide transferase (1962), Methods Enzymol., 5, 486-488.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.3 Ba2+
-
 Gallus gallus
2.7.8.3 Ca2+
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.3 microsome
-
 Gallus gallus
-
-
2.7.8.3 mitochondrion
-
 Gallus gallus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.3 Mg2+ activates to a lesser extent than Mn2+ Gallus gallus
2.7.8.3 Mn2+ required for optimum activity Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.3 cytidine diphosphate choline + N-acyl-threo-trans-sphingosine Gallus gallus
-
 CMP + sphingomyelin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.3 Gallus gallus
-
 chicken
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.3 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.3 cytidine diphosphate choline + N-acetyl-DL-threo-trans-sphingosine
-
 Gallus gallus CMP + sphingomyelin
-
 ?
2.7.8.3 cytidine diphosphate choline + N-acyl-threo-trans-sphingosine
-
 Gallus gallus CMP + sphingomyelin
-
 ?
2.7.8.3 additional information highly specific for CDP-choline, active with ceramides containing isomers of sphingosine with the threo configuration of the substituents at carbons 2 and 3, and with trans double bond or triple bond at carbon 4, much less active if the sphingosine moiety has the erythro configuration or a cis double bond Gallus gallus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.3 7.8
-
-
 Gallus gallus