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Literature summary extracted from

  • Kukuruzinska, M.A.; Lennon, K.
    Diminished activity of the first N-glycosylation enzyme, dolichol-P-dependent N-acetylglucosamine-1-P transferase (GPT), gives rise to mutant phenotypes in yeast (1995), Biochim. Biophys. Acta, 1247, 51-59.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.15 UDP-N-acetyl-D-glucosamine + dolichyl phosphate Saccharomyces cerevisiae the enzyme initiates the dolichol pathway of protein N-glycosylation. A 2.5- to 4fold reduction in enzyme activity gives rise to distinct phenotypes, whose severity is inversely related to the level of enzyme activity. These phenotypes include hypersensitivity to tunicamycin, enlarged cell size, extensive aggregation, lack of typical stationary arrest and defective spore germination ?
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Organism

EC Number Organism UniProt Comment Textmining
2.7.8.15 Saccharomyces cerevisiae
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.15 UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
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Saccharomyces cerevisiae UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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2.7.8.15 UDP-N-acetyl-D-glucosamine + dolichyl phosphate the enzyme initiates the dolichol pathway of protein N-glycosylation. A 2.5- to 4fold reduction in enzyme activity gives rise to distinct phenotypes, whose severity is inversely related to the level of enzyme activity. These phenotypes include hypersensitivity to tunicamycin, enlarged cell size, extensive aggregation, lack of typical stationary arrest and defective spore germination Saccharomyces cerevisiae ?
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