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Literature summary extracted from

  • Heifetz, A.; Keenan, R.W.; Elbein, A.D.
    Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate Glc-NAc-1-phosphate transferase (1979), Biochemistry, 18, 2186-2192.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.15 phosphatidylcholine 0.001 mM/ml, 30-40% inhibition Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.15 tunicamycin 0.00005-0.0001 mg/ml, 50% inhibition, noncompetitive with respect to UDP-GlcNAc or dolichyl phosphate, both directions Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.15 0.0002
-
 UDP-GlcNAc 37°C Sus scrofa
2.7.8.15 0.0007
-
 dolichyl phosphate 37°C Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.15 microsome
-
 Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.15 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.15 aorta
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.15 UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Sus scrofa UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?
2.7.8.15 UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Sus scrofa UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 r