Literature summary extracted from

Zawadzke, L.E.; Wu, P.; Cook, L.; Fan, L.; Casperson, M.; Kishnani, M.; Calambur, D.; Hofstead, S.J.; Padmanabha, R.
Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention (2003), Anal. Biochem., 314, 243-252.

Application

EC Number	Application	Comment	Organism
2.7.8.13	medicine	target for antimicrobial therapeutic intervention, novel antibiotic chemotypes must be developed to deter the alarming rate of antibiotic resistance growth	Escherichia coli

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.7.8.13	mraY gene cloned into pASK-IBA3 vector and overexpressed	Escherichia coli

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.8.13	additional information	MraY natural product inhibitors are not broad in spectrum nor practical for general antibiotic use	Escherichia coli
2.7.8.13	mureidomycin A	inhibitor isolated from Streptomyces flavidovirens WD31235, also antibacterial activity against Pseudomonas aeruginosa A27853	Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.8.13	UDP-MurNAc-pentapeptide + undecaprenyl-phosphate	Escherichia coli	-	UMP + MurNAc-pentapeptide diphosphoryl undecaprenol	-	r
2.7.8.13	UDP-NAc-muramoyl-pentapeptide + acceptor	Escherichia coli	-	UMP + acceptor-phospho-NAc-muramoyl-pentapeptide	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.8.13	Escherichia coli	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.7.8.13	-	Escherichia coli

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.8.13	UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate	-	Escherichia coli	lipid-P-P-MurNAc-pentapeptide + UMP	-	r
2.7.8.13	UDP-MurNAc-pentapeptide + undecaprenyl-phosphate	-	Escherichia coli	UMP + MurNAc-pentapeptide diphosphoryl undecaprenol	-	r
2.7.8.13	UDP-NAc-muramoyl-pentapeptide + acceptor	-	Escherichia coli	UMP + acceptor-phospho-NAc-muramoyl-pentapeptide	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.8.13	MraY protein	-	Escherichia coli

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Release 2023.1 (January 2023)