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Literature summary extracted from

  • Pless, D.D.; Neuhaus, F.C.
    Initial membrane reaction in peptidoglycan synthesis. Lipid dependence of phospho-n-acetylmuramyl-pentapeptide translocase (exchange reaction) (1973), J. Biol. Chem., 248, 1568-1576.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.13 undecaprenyl phosphate stimulates exchange reaction Staphylococcus aureus
2.7.8.13 Undecaprenyl-diphosphate-MurNAc-pentapeptide stimulates exchange reaction Staphylococcus aureus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.13 Mg2+
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.13 UDP-NAc-muramoyl-pentapeptide + acceptor Staphylococcus aureus initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
 r
2.7.8.13 UDP-NAc-muramoyl-pentapeptide + acceptor Staphylococcus aureus Copenhagen initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.13 Staphylococcus aureus
-
 Copenhagen
-
2.7.8.13 Staphylococcus aureus Copenhagen
-
 Copenhagen
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.13 UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
-
 Staphylococcus aureus lipid-P-P-MurNAc-pentapeptide + UMP
-
 r
2.7.8.13 UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
-
 Staphylococcus aureus Copenhagen lipid-P-P-MurNAc-pentapeptide + UMP
-
 r
2.7.8.13 UDP-NAc-muramoyl-pentapeptide + acceptor
-
 Staphylococcus aureus UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
 r
2.7.8.13 UDP-NAc-muramoyl-pentapeptide + acceptor initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis Staphylococcus aureus UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
 r
2.7.8.13 UDP-NAc-muramoyl-pentapeptide + acceptor
-
 Staphylococcus aureus Copenhagen UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
 r
2.7.8.13 UDP-NAc-muramoyl-pentapeptide + acceptor initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis Staphylococcus aureus Copenhagen UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
 r