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Literature summary extracted from
- Molecular cloning, functional complementation in Saccharomyces cerevisiae and enzymatic properties of phosphatidylinositol synthase from the protozoan parasite Toxoplasma gondii (2000), Eur. J. Biochem., 267, 6571-6579.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 2.7.8.11 | medicine | causative agent of toxoplasmosis, screening of drugs against the parasite enzyme | Toxoplasma gondii |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.7.8.11 | - |
Toxoplasma gondii |
| 2.7.8.11 | cDNA cloned by functional complementation in Saccharomyces cerevisiae | Toxoplasma gondii |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.8.11 | Mg2+ | - |
Toxoplasma gondii |  |
| 2.7.8.11 | Mn2+ | - |
Toxoplasma gondii | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.7.8.11 | 27800 | - |
calculated from cDNA | Toxoplasma gondii |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol | Toxoplasma gondii | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol | Toxoplasma gondii 76K | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.8.11 | Toxoplasma gondii | - |
cDNA fragment TgPIS1 encoding PtIns synthase | - |
| 2.7.8.11 | Toxoplasma gondii | Q9XY91 | cDNA fragment TgPIS2 potentially encoding PtIns synthase | - |
| 2.7.8.11 | Toxoplasma gondii 76K | - |
cDNA fragment TgPIS1 encoding PtIns synthase | - |
| 2.7.8.11 | Toxoplasma gondii 76K | Q9XY91 | cDNA fragment TgPIS2 potentially encoding PtIns synthase | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol | - |
Toxoplasma gondii | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol | - |
Toxoplasma gondii 76K | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.8.11 | PtIns synthase | - |
Toxoplasma gondii |
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