Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bravo, I.G.; Reglero, A.
    The cytidyltransferases family: Properties, kinetics, genomic and phylogeny (2003), Recent Res. Devel. Biochem., 4, 224-254.
No PubMed abstract available

Application

EC Number Application Comment Organism
2.7.7.38 medicine
-
 Escherichia coli
2.7.7.38 medicine KDO is not present in animals but is vital for gram-negative bacteria, suggests the possibility of using selective inhibition of its synthesis as antibacterial tool Haemophilus influenzae

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.38
-
 Escherichia coli
2.7.7.38 KDO-CT crystallized in presence of CMP-NeuAc, crystallizes as a dimer composed of 27kDa monomers Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.38 2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate
-
 Escherichia coli
2.7.7.38 2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate
-
 Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.38 0.024 0.8 CTP
-
 Escherichia coli
2.7.7.38 0.024 0.8 CTP
-
 Zea mays
2.7.7.38 0.29
-
 3-deoxy-D-manno-octulosonate
-
 Escherichia coli
2.7.7.38 0.9
-
 3-deoxy-D-manno-octulosonate
-
 Escherichia coli
2.7.7.38 2.5
-
 CTP isoenzyme K-KDO-CT Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.38 Ba2+ can partially substitute Mg2+ Escherichia coli
2.7.7.38 Ca2+ can partially substitute Mg2+ Escherichia coli
2.7.7.38 Cd2+ can partially substitute Mg2+ Escherichia coli
2.7.7.38 Co2+ can partially substitute Mg2+ Escherichia coli
2.7.7.38 Mn2+ can partially substitute Mg2+ Escherichia coli
2.7.7.38 Zn2+ can partially substitute Mg2+ Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Salmonella enterica subsp. enterica serovar Typhimurium
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Chlamydia trachomatis
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Haemophilus influenzae
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Escherichia coli
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Zea mays
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Pseudomonas aeruginosa
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Neisseria meningitidis
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Helicobacter pylori
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Rickettsia prowazekii
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Aquifex aeolicus
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Chlamydia muridarum
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Chlamydia pneumoniae
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Pasteurella multocida
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Arabidopsis thaliana
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Caulobacter vibrioides
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Mesorhizobium loti
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Rickettsia conorii
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Sinorhizobium meliloti
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Vibrio cholerae
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Xylella fastidiosa
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Neisseria meningitidis MC58
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.38 Aquifex aeolicus
-
-
-
2.7.7.38 Arabidopsis thaliana Q9C920
-
-
2.7.7.38 Caulobacter vibrioides Q9A4A3
-
-
2.7.7.38 Chlamydia muridarum
-
-
-
2.7.7.38 Chlamydia pneumoniae
-
-
-
2.7.7.38 Chlamydia trachomatis
-
-
-
2.7.7.38 Escherichia coli
-
-
-
2.7.7.38 Escherichia coli P42216 PDB: 1H7F, 3-dimensional structure of KDO-CT, in presence of CMP
-
2.7.7.38 Escherichia coli P42216 PDB: 1H7T, 3-dimensional structure of KDO-CT, in presence of CMP-NeuAc
-
2.7.7.38 Escherichia coli P42216 PDB: 1H7H, 3-dimensional structure of KDO-CT, in presence of CTP
-
2.7.7.38 Escherichia coli P42216 PDB: 1H7G, 3-dimensional structure of KDO-CT, in presence of CDP
-
2.7.7.38 Escherichia coli P42216 PDB:1H7E, 3-dimensional structure of KDO-CT, unligated form
-
2.7.7.38 Haemophilus influenzae
-
-
-
2.7.7.38 Helicobacter pylori
-
-
-
2.7.7.38 Mesorhizobium loti Q98BN3
-
-
2.7.7.38 Neisseria meningitidis
-
-
-
2.7.7.38 Neisseria meningitidis Q9K0D6 strain B
-
2.7.7.38 Neisseria meningitidis MC58 Q9K0D6 strain B
-
2.7.7.38 Pasteurella multocida
-
-
-
2.7.7.38 Pseudomonas aeruginosa
-
-
-
2.7.7.38 Rickettsia conorii Q92I96
-
-
2.7.7.38 Rickettsia prowazekii
-
-
-
2.7.7.38 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
2.7.7.38 Sinorhizobium meliloti Q92SX6
-
-
2.7.7.38 Vibrio cholerae Q9KQX2
-
-
2.7.7.38 Xylella fastidiosa Q9PB46
-
-
2.7.7.38 Zea mays
-
 maize
-
2.7.7.38 Zea mays Q9M4D3 maize, KDO-CT fragment
-
2.7.7.38 Zea mays Q9M4G3 maize, KDO-CT precursor
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Chlamydia trachomatis diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Haemophilus influenzae diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Escherichia coli diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Zea mays diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Pseudomonas aeruginosa diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Neisseria meningitidis diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Helicobacter pylori diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Rickettsia prowazekii diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Aquifex aeolicus diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Chlamydia muridarum diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Chlamydia pneumoniae diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Pasteurella multocida diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Arabidopsis thaliana diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Caulobacter vibrioides diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Mesorhizobium loti diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Rickettsia conorii diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Sinorhizobium meliloti diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Vibrio cholerae diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Xylella fastidiosa diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Neisseria meningitidis MC58 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 dCTP + 3-deoxy-D-manno-octulosonate
-
 Chlamydia trachomatis diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 dCTP + 3-deoxy-D-manno-octulosonate
-
 Escherichia coli diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 additional information
-
 Chlamydia trachomatis ?
-
 ?
2.7.7.38 additional information 3-deoxy-D-manno-octulosonate-8-phosphate is no substrate, neither NeuAc nor 3-deoxy-arabinoheptulosonate or 3-deoxy-erythro-hexulosonate are substrates Escherichia coli ?
-
 ?
2.7.7.38 UTP + 3-deoxy-D-manno-octulosonate 12% of the activity with CTP as substrate Chlamydia trachomatis diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 UTP + 3-deoxy-D-manno-octulosonate nearly the same activity with CTP as pH 9.5, more active with CTP at pH 7.0 Zea mays diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
 r
2.7.7.38 UTP + 3-deoxy-D-manno-octulosonate reaction at pH 9.5, approximately 50% the rate with CTP Escherichia coli diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.7.38 K-KDO-CT
-
 Escherichia coli
2.7.7.38 KDO-CT
-
 Escherichia coli
2.7.7.38 L-KDO-CT
-
 Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.38 9.3 9.6
-
 Escherichia coli