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Literature summary extracted from

  • Hansen, R.G.; Verachtert, H.; Rodriguez, P.; Bass, S.T.
    GDP-hexose pyrophosphorylase from liver (1966), Methods Enzymol., 8, 269-271.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.28 D-mannose 1-phosphate
-
 Bos taurus
2.7.7.28 GDPmannose
-
 Bos taurus
2.7.7.28 Zn2+ inhibits when added with Mg2+, Mn2+ or Co2+ Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.28 0.0001
-
 GDPmannose
-
 Bos taurus
2.7.7.28 0.082
-
 diphosphate
-
 Bos taurus
2.7.7.28 2.6
-
 GTP
-
 Bos taurus
2.7.7.28 2.6
-
 D-glucose 1-phosphate
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.28 Mg2+ required Bos taurus
2.7.7.28 Mn2+ metal requirement can be partially met by Mn2+ Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.28 ADPmannose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose ATP + D-mannose 1-phosphate
-
 ?
2.7.7.28 GDP-glucose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose GTP + D-glucose 1-phosphate
-
 r
2.7.7.28 GDPmannose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose GTP + D-mannose 1-phosphate
-
 ?
2.7.7.28 IDP-glucose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose ITP + D-glucose 1-phosphate
-
 ?
2.7.7.28 IDPmannose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose ITP + D-mannose 1-phosphate
-
 r
2.7.7.28 UDPglucose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose UTP + D-glucose 1-phosphate
-
 ?
2.7.7.28 UDPmannose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose UTP + D-mannose 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.28 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.28
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.28 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.28 0.38
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.28 ADPmannose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus ATP + D-mannose 1-phosphate
-
 ?
2.7.7.28 GDP-glucose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus GTP + D-glucose 1-phosphate
-
 r
2.7.7.28 GDPmannose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus GTP + D-mannose 1-phosphate
-
 ?
2.7.7.28 IDP-glucose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus ITP + D-glucose 1-phosphate
-
 ?
2.7.7.28 IDPmannose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus ITP + D-mannose 1-phosphate
-
 r
2.7.7.28 UDPglucose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus UTP + D-glucose 1-phosphate
-
 ?
2.7.7.28 UDPmannose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus UTP + D-mannose 1-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.28 7.5 8
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.28 0.00017
-
 GDP-mannose
-
 Bos taurus
2.7.7.28 0.047
-
 D-mannose 1-phosphate
-
 Bos taurus