EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.4.9 | histidine-tagged enzyme, overexpression in Escherichia coli | Streptococcus pneumoniae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.9 | ADP | ADP[beta-S] | Streptococcus pneumoniae | |
2.7.4.9 | dTDP | - |
Streptococcus pneumoniae | |
2.7.4.9 | dTMP | - |
Streptococcus pneumoniae |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.9 | 0.066 | - |
dTMP | pH 8.5, 25°C | Streptococcus pneumoniae | |
2.7.4.9 | 0.235 | - |
ATP | pH 8.5, 25°C | Streptococcus pneumoniae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.9 | ATP + dTMP | Streptococcus pneumoniae | reaction in both the de novo and salvage pathways of dTTP synthesis | ADP + dTDP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.9 | Streptococcus pneumoniae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.4.9 | - |
Streptococcus pneumoniae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.9 | ATP + 3'-azido-3'-deoxythymidine 5'-monophosphate | no activity | Streptococcus pneumoniae | ADP + 3'-azido-3'-deoxythymidine 5'-diphosphate | - |
? | |
2.7.4.9 | ATP + dTMP | - |
Streptococcus pneumoniae | ADP + dTDP | - |
? | |
2.7.4.9 | ATP + dTMP | reaction in both the de novo and salvage pathways of dTTP synthesis | Streptococcus pneumoniae | ADP + dTDP | - |
? | |
2.7.4.9 | ATP + dUMP | 15% of the activity with dTMP | Streptococcus pneumoniae | ADP + dUDP | - |
? | |
2.7.4.9 | CTP + dTMP | 20% of the activity with ATP | Streptococcus pneumoniae | CDP + dTDP | - |
? | |
2.7.4.9 | dATP + dTMP | 80% of the activity with ATP | Streptococcus pneumoniae | dADP + dTDP | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.9 | 8.9 | - |
ATP | pH 8.5, 25°C | Streptococcus pneumoniae | |
2.7.4.9 | 8.9 | - |
dTMP | pH 8.5, 25°C | Streptococcus pneumoniae |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.4.9 | 8.5 | - |
- |
Streptococcus pneumoniae |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.7.4.9 | 7 | 9.5 | pH 7.0: about 40% of maximal activity, pH 9.5: about 55% of maximal activity | Streptococcus pneumoniae |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.9 | 0.047 | - |
ADP | pH 8.5, 25°C, with ATP as variable substrate | Streptococcus pneumoniae | |
2.7.4.9 | 0.16 | - |
dTMP | pH 8.5, 25°C, dTMP as variable substrate | Streptococcus pneumoniae | |
2.7.4.9 | 0.415 | - |
ADP | pH 8.5, 25°C, with dTMP as variable substrate | Streptococcus pneumoniae |