EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.9 | 5-iodo-5'-fluoro-2',5'-dideoxyuridine | - |
Human alphaherpesvirus 1 | |
2.7.4.9 | 5-iodo-dUMP | competitive versus both thymidylate and thymidine | Human alphaherpesvirus 1 | |
2.7.4.9 | ADP | ADP*Mg2+ product inhibition, competitive versus MgATP2-, noncompetitive versus thymidylate | Human alphaherpesvirus 1 | |
2.7.4.9 | dTDP | product inhibition, competitive versus MgATP2- | Human alphaherpesvirus 1 | |
2.7.4.9 | dTTP | competitive versus both thymidine and thymidylate | Human alphaherpesvirus 1 | |
2.7.4.9 | MgADP- | - |
Human alphaherpesvirus 1 |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.9 | Human alphaherpesvirus 1 | - |
thymidine/thymidylate multifunctional kinase | - |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.7.4.9 | ATP + dTMP = ADP + dTDP | addition of substrates to the enzyme is random, while release of the products is ordered | Human alphaherpesvirus 1 |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.9 | additional information | thymidine/thymidylate multifunctional kinase | Human alphaherpesvirus 1 | ? | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.9 | 0.0006 | - |
5-iodo-5'-fluoro-2',5'-dideoxyuridine | versus thymidylate | Human alphaherpesvirus 1 | |
2.7.4.9 | 0.0009 | - |
5-iodo-5'-fluoro-2',5'-dideoxyuridine | versus thymidine | Human alphaherpesvirus 1 | |
2.7.4.9 | 0.05 | - |
dTTP | verus thymidylate | Human alphaherpesvirus 1 | |
2.7.4.9 | 0.059 | - |
dTDP | versus thymidylate | Human alphaherpesvirus 1 | |
2.7.4.9 | 0.06 | - |
MgADP- | versus ATP*Mg2+ | Human alphaherpesvirus 1 | |
2.7.4.9 | 0.062 | - |
dTTP | versus thymidine | Human alphaherpesvirus 1 | |
2.7.4.9 | 0.1 | - |
MgADP- | versus thymidylate | Human alphaherpesvirus 1 |