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Literature summary extracted from

  • Chen, M.C.; Walker, J.; Prusoff, W.H.
    Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme (1979), J. Biol. Chem., 254, 10747-10753.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.9 5-iodo-5'-fluoro-2',5'-dideoxyuridine
-
 Human alphaherpesvirus 1
2.7.4.9 5-iodo-dUMP competitive versus both thymidylate and thymidine Human alphaherpesvirus 1
2.7.4.9 ADP ADP*Mg2+ product inhibition, competitive versus MgATP2-, noncompetitive versus thymidylate Human alphaherpesvirus 1
2.7.4.9 dTDP product inhibition, competitive versus MgATP2- Human alphaherpesvirus 1
2.7.4.9 dTTP competitive versus both thymidine and thymidylate Human alphaherpesvirus 1
2.7.4.9 MgADP-
-
 Human alphaherpesvirus 1

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.9 Human alphaherpesvirus 1
-
 thymidine/thymidylate multifunctional kinase
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.4.9 ATP + dTMP = ADP + dTDP addition of substrates to the enzyme is random, while release of the products is ordered Human alphaherpesvirus 1
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.9 additional information thymidine/thymidylate multifunctional kinase Human alphaherpesvirus 1 ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.4.9 0.0006
-
 5-iodo-5'-fluoro-2',5'-dideoxyuridine versus thymidylate Human alphaherpesvirus 1
2.7.4.9 0.0009
-
 5-iodo-5'-fluoro-2',5'-dideoxyuridine versus thymidine Human alphaherpesvirus 1
2.7.4.9 0.05
-
 dTTP verus thymidylate Human alphaherpesvirus 1
2.7.4.9 0.059
-
 dTDP versus thymidylate Human alphaherpesvirus 1
2.7.4.9 0.06
-
 MgADP- versus ATP*Mg2+ Human alphaherpesvirus 1
2.7.4.9 0.062
-
 dTTP versus thymidine Human alphaherpesvirus 1
2.7.4.9 0.1
-
 MgADP- versus thymidylate Human alphaherpesvirus 1