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Literature summary extracted from

  • Van Rompay, A.R.; Johansson, M.; Karlsson, A.
    Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme (1999), Mol. Pharmacol., 56, 562-569.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.14 expression in Escherichia coli. The 228-aa and the 196-11 form are expressed as His-tagged fusion protein. The 196-aa UMP/CMP kinase is the actual form of the enzyme Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.14 0.45
-
2',2'-difluorodeoxycytidine pH 8.0, 37°C Homo sapiens
2.7.4.14 0.5
-
CMP pH 8.0, 37°C Homo sapiens
2.7.4.14 1.4
-
araCMP pH 8.0, 37°C Homo sapiens
2.7.4.14 1.6
-
UMP pH 8.0, 37°C Homo sapiens
2.7.4.14 5.9
-
dUMP pH 8.0, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.14 cytosol
-
Homo sapiens 5829
-
2.7.4.14 nucleus
-
Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.14 Homo sapiens P30085
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.14 ATP + 1-beta-D-arabinofuranosylcytosine
-
Homo sapiens ADP + ?
-
?
2.7.4.14 ATP + 2',2'-difluorodeoxycytidine
-
Homo sapiens ADP + ?
-
?
2.7.4.14 ATP + AMP
-
Homo sapiens ADP + ADP
-
r
2.7.4.14 ATP + ara-CMP
-
Homo sapiens ADP + ara-CDP
-
?
2.7.4.14 ATP + CMP
-
Homo sapiens ADP + CDP
-
?
2.7.4.14 ATP + dAMP
-
Homo sapiens ADP + dADP
-
?
2.7.4.14 ATP + dCMP
-
Homo sapiens ADP + dCDP
-
?
2.7.4.14 ATP + dUMP
-
Homo sapiens ADP + dUDP
-
?
2.7.4.14 ATP + UMP
-
Homo sapiens ADP + UDP
-
?