Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Skórko, R.; Osipiuk, J.; Stetter, K.O.
    Glycogen-bound polyphosphate kinase from the archaebacterium Sulfolobus acidocaldarius (1989), J. Bacteriol., 171, 5162-5164.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.4.1 additional information only active as glycogen-enzyme complex Sulfolobus acidocaldarius

General Stability

EC Number General Stability Organism
2.7.4.1 enzymatic hydrolysis of glycogen inactivates Sulfolobus acidocaldarius

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.1 ADP 2 mM, 50% inhibition of glycogen-bound polyphosphate kinase; product inhibition, about 50% inhibition at 2 mM Sulfolobus acidocaldarius
2.7.4.1 ammonium hydrochloride 50% inhibition at 200 mM Sulfolobus acidocaldarius
2.7.4.1 ATP 20% substrate inhibition at 2.4 mM Sulfolobus acidocaldarius
2.7.4.1 F- 2 mM, 25% inhibition of glycogen-bound polyphosphate kinase Sulfolobus acidocaldarius
2.7.4.1 hydrolyzed glycogen complete inhibition Sulfolobus acidocaldarius
2.7.4.1 additional information enzymatic hydrolysis of glycogen Sulfolobus acidocaldarius
2.7.4.1 NH4Cl 200 mM, approx. 50% inhibition of glycogen-bound polyphosphate kinase Sulfolobus acidocaldarius
2.7.4.1 phosphate 2 mM, 50% inhibition of glycogen-bound polyphosphate kinase; strong inhibition Sulfolobus acidocaldarius
2.7.4.1 Polyphosphate substrate inhibition at 2 mM Sulfolobus acidocaldarius
2.7.4.1 Sodium fluoride slight inhibition Sulfolobus acidocaldarius

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.1 additional information
-
additional information exponential kinetics Sulfolobus acidocaldarius
2.7.4.1 0.075
-
ATP pH 7.0, 75°C Sulfolobus acidocaldarius
2.7.4.1 0.075
-
ATP pH 7.0, 75°C, glycogen-complexed enzyme Sulfolobus acidocaldarius

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.1 additional information glycogen-bound Sulfolobus acidocaldarius
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.1 K+ activation Sulfolobus acidocaldarius
2.7.4.1 KCl activates Sulfolobus acidocaldarius
2.7.4.1 Mg2+ stimulates Sulfolobus acidocaldarius
2.7.4.1 Mg2+ activation Sulfolobus acidocaldarius
2.7.4.1 Mg2+ 50% as effective as Mn2+ Sulfolobus acidocaldarius
2.7.4.1 Mn2+ maximal activity at 2 mM Sulfolobus acidocaldarius
2.7.4.1 Mn2+ stimulates, preferred metal ion Sulfolobus acidocaldarius

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.1 57000
-
x * 57000, glycogen-complexed enzyme, SDS-PAGE Sulfolobus acidocaldarius

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.1 ATP + (phosphate)n Sulfolobus acidocaldarius
-
ADP + (phosphate)n+1
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.1 Sulfolobus acidocaldarius
-
-
-
2.7.4.1 Sulfolobus acidocaldarius
-
strain DSM 639
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.4.1 additional information glycogen-bound polyphosphate kinase Sulfolobus acidocaldarius

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.1 native enzyme as glycogen complex partially from crude extract by isopycnic centrifugation in CsCl, followed by dialysis Sulfolobus acidocaldarius
2.7.4.1 partial purification Sulfolobus acidocaldarius

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.1 ATP + (phosphate)n
-
Sulfolobus acidocaldarius ADP + (phosphate)n+1
-
?
2.7.4.1 ATP + (phosphate)n glycogen-bound polyphosphate kinase Sulfolobus acidocaldarius ADP + (phosphate)n+1
-
?
2.7.4.1 ATP + (phosphate)n the enzyme does not require the presence of histones for its activity Sulfolobus acidocaldarius ADP + (phosphate)n+1
-
?

Subunits

EC Number Subunits Comment Organism
2.7.4.1 ? x * 57000, glycogen-complexed enzyme, SDS-PAGE Sulfolobus acidocaldarius

Synonyms

EC Number Synonyms Comment Organism
2.7.4.1 glycogen-bound polyphosphate kinase
-
Sulfolobus acidocaldarius
2.7.4.1 poly-P kinase
-
Sulfolobus acidocaldarius

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.4.1 75
-
-
Sulfolobus acidocaldarius
2.7.4.1 75
-
assay at Sulfolobus acidocaldarius

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.4.1 7
-
assay at Sulfolobus acidocaldarius

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.4.1 ATP
-
Sulfolobus acidocaldarius

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.4.1 Sulfolobus acidocaldarius several spots, isoelectric focusing 6.7 5.6